ArticleNature communications2021
In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- Article
- Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice.eLife · 2023Article
- Article
- Advantages, Pitfalls, and Developments of All Optical Interrogation Strategies of MicrocircuitsFrontiers in neuroscience · 2022Review
- Modernizing the NEURON Simulator for Sustainability, Portability, and Performance.Frontiers in neuroinformatics · 2022Article
- Carbon fiber electrodes for intracellular recording and stimulation.Journal of neural engineering · 2021Article
- In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations.Nature communications · 2021Article
- Interstitial ions: A key regulator of state-dependent neural activity?Progress in neurobiology · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-sensitive dye imaging (VSDI) is a powerful technique for interrogating membrane potential dynamics in assemblies of cortical neurons, but with effective resolution limits that confound interpretation. To address this limitation, we developed an in silico model of VSDI in a biologically faithful digital reconstruction of rodent neocortical microcircuitry. Using this model, we extend previous experimental observations regarding the cellular origins of VSDI, finding that the signal is driven primarily by neurons in layers 2/3 and 5, and that VSDI measurements do not capture individual spikes. Furthermore, we test the capacity of VSD image sequences to discriminate between afferent thalamic inputs at various spatial locations to estimate a lower bound on the functional resolution of VSDI. Our approach underscores the power of a bottom-up computational approach for relating scales of cortical processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.