Evidence map›Paper›PMID 34130995›Full record

ArticleLife science alliance2021

DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.

Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian Jf Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 2 countries.

Hidenori HommaDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Hikari TanakaDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Meihua JinDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Xiaocen JinDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Yong HuangDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Yuki YoshiokaDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Christian Jf BertensDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0001-5710-3703
Kohei TsumakiDepartment of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan.
Kanoh KondoDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroki ShiwakuDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Kazuhiko TagawaDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroyasu AkatsuDepartment of Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Naoki AtsutaDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masahisa KatsunoDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Katsutoshi FurukawaDivision of Community Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.ORCID 0000-0002-8047-4606
Aiko IshikiDepartment of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Masaaki WaragaiDepartment of Neurology, Higashi Matsudo Municipal Hospital, Chiba, Japan.
Gaku OhtomoDepartment of Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0002-9674-5271
Atsushi IwataDepartment of Neurology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0001-7308-5314
Takanori YokotaDepartment of Neurology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Haruhisa InoueCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Hiroyuki AraiDepartment of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Gen SobueDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masaki SoneDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Kyota FujitaDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Hitoshi OkazawaDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan okazawa-tky@umin.ac.jp.ORCID 0000-0002-6127-5046
Tokyo Medical and Dental University · JPNagoya University · JPThe University of Tokyo · JPTohoku University · JPKyoto University · JPMatsudo City Hospital · JPNagoya City University · JPTohoku Medical and Pharmaceutical University · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely unknown. In VCP

Indexed as

AnimalsCell CycleCell LineageCells, CulturedDNA-Binding ProteinsDNA DamageFrontotemporal Lobar DegenerationGene ExpressionGene Expression RegulationMiceMice, Inbred C57BLMutationNecrosisNeural Stem CellsNeuronsValosin Containing ProteinDNA-Binding ProteinsValosin Containing ProteinVcp protein, mouse

Identifiers

PMID34130995
PMCPMC9715434
OpenAlexW3172307221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.