ArticleStem cells and development2021
Histology Scoring System for Murine Cutaneous Wounds.
Article in Stem cells and development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 86 citations in OpenAlex.
- MAP Crosslinker Chirality Regulates Macrophage Polarization Through MD-2 Engagement and Enables Tunable Immunomodulation Through Novel Peptide Design.Advanced healthcare materials · 2026Article
- Systemic humoral activation facilitates tissue regeneration by D-chiral biomaterial scaffolds.Cell biomaterials · 2026Article
- Honeybee venom modulates antioxidant gene expression and tissue regeneration in a rat model of staphylococcus aureus - infected skin wounds.Molecular biology reports · 2026Article
- Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models.Materials today. Bio · 2026Article
- Characterization and Wound-Healing Effects of Fucoidan from Sargassum polycystum Collected in South Sulawesi in a Staphylococcus aureus-Infected Rat Model.Marine biotechnology (New York, N.Y.) · 2026Article
- Short-Term Nicotine Improves Experimental Flap Survival: Implications for Different Findings in Experimental Flap Models.Medicina (Kaunas, Lithuania) · 2026Article
- Time-dependent effects of topical mucopolysaccharide polysulfate and silver sulfadiazine on wound healing in a rat excisional wound model.Joint diseases and related surgery · 2026Article
- Tower-shaped super-adhesive microneedles loaded with vitamin A-containing Bletilla striata vesicles: temporally regulated Inflammation resolution and ECM remodeling for scarless wound healing.Journal of nanobiotechnology · 2026Article
- iPSC-derived exosomes promote diabetic wound healing by attenuating inflammatory responses.Stem cell research & therapy · 2026Article
- Topical wound-care products and their effects on healing, inflammatory biomarkers, and growth in piglets undergoing castration.Porcine health management · 2026Article
- Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds.Science advances · 2026Article
- Enhanced Burn Wound Healing and Conversion Prevention Through Inhibition of High Mobility Group Box 1 in a Scald Burn Rat Model.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Comparative effects of Pistacia atlantica leaf and phenytoin ointment on rat skin wound healing: histopathological changes and bioactive compounds.Inflammopharmacology · 2026Article
- Endothelial progenitor cell derived extracellular vesicles promotes wound healing in diabetic mice via activating mobilization and neovascularization.Cell biology and toxicology · 2026Article
- Pachymic Acid Accelerated Diabetic Ulcer Healing by Enhancing Macrophage Efferocytosis via the MEK/ERK/TGFβ1 Signaling Axis.Journal of diabetes research · 2026Article
- Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026Article
- The Split-Level Folding, Step-Type Tension-Relieving Suture Technique Improves the Wound Tensile Strength.Aesthetic plastic surgery · 2026Article
- Article
- A novel chitosan-collagen bilayer scaffold prevents contraction and accelerates cutaneous repair in a rat splint-skin model.Frontiers in bioengineering and biotechnology · 2026Article
- A Novel Murine Model for Studying Impaired Wound Healing in Diabetes.International wound journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
Abstract
Monitoring wound progression over time is a critical aspect for studies focused on in-depth molecular analysis or on evaluating the efficacy of potential novel therapies. Histopathological analysis of wound biopsies can provide significant insight into healing dynamics, yet there is no standardized and reproducible scoring system currently available. The purpose of this study was to develop and statistically validate a scoring system based on parameters in each phase of healing that can be easily and accurately assessed using either Hematoxylin & Eosin (H&E) or Masson's Trichrome (MT) staining. These parameters included re-epithelization, epithelial thickness index, keratinization, granulation tissue thickness, remodeling, and the scar elevation index. The initial phase of the study was to (1) optimize and clarify healing parameters to limit investigator bias and variability; (2) compare the consistency of parameters assessed using H&E versus MT staining. During the validation phase of this study, the accuracy and reproducibility of this scoring system was independently iterated upon and validated in four different types of murine skin wound models (Excisional; punch biopsy; pressure ulcers; burn wounds). A total of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.