ArticlePsychiatry investigation2021
Association of Prefrontal Cortex Thinning with High Impulsivity in Healthy Adults.
Article in Psychiatry investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cortical Microstructural Variations Correlate With Individual Differences in Gamified Exploration-Exploitation Behaviours.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder.Psychological medicine · 2025Article
- Multimodal objective assessment of impulsivity in healthy and mood disorder participants.NPP - digital psychiatry and neuroscience · 2025Article
- Age-dependent mechanisms of exercise in the treatment of depression: a comprehensive review of physiological and psychological pathways.Frontiers in psychology · 2025Review
- Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach.Sensors (Basel, Switzerland) · 2023Article
- Motor impulsivity but not risk-related impulsive choice is associated to drug intake and drug-primed relapse.Frontiers in behavioral neuroscience · 2023Article
- Association of DNA Methylation of theInternational journal of molecular sciences · 2022Article
- The Indirect Effect of Prefrontal Gray Matter Volume on Suicide Attempts among Individuals with Major Depressive Disorder.Experimental neurobiology · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveStudies have been conducted to identify brain structural alterations related to high impulsivity in psychiatric populations. However, research on healthy subjects is relatively less extensive. Therefore, we aimed to investigate the correlation between the cortical thickness of whole brain regions and the impulsivity level in a healthy population.
methodsWe included 100 healthy participants aged 19-65 years. Their T1-weighted magnetic resonance images and the 23-item Barratt Impulsiveness Scale (BIS) score were obtained. The patients were divided into high and low impulsivity groups according to the 75th percentile score of the BIS in the sample. The thickness of each cortical region was calculated using the FreeSurfer, and the difference in cortical thickness of the whole brain between the high and low impulsivity groups was analyzed using one-way analysis of covariance including age, sex, education level, and total intracranial cavity volume as covariates.
resultsThe high impulsivity group showed significant cortical thinning in the left pars opercularis. The cortical thickness of the left pars opercularis significantly correlated negatively with the total, attention, and motor scores of the BIS scale.
conclusionOur findings suggest that prefrontal cortex thinning may play an important role in the development of high impulsivity in healthy adults.
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