ArticleParasitology research1988
Triton-labile antigens in flagella isolated from Giardia lamblia.
Article in Parasitology research, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Microtubule organelles in Giardia.Advances in parasitology · 2020Review
- Article
- Hybrid Structured Illumination Expansion Microscopy Reveals Microbial Cytoskeleton Organization.ACS nano · 2017Article
- Review
- High-speed microscopic imaging of flagella motility and swimming in Giardia lamblia trophozoites.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Life with eight flagella: flagellar assembly and division in Giardia.Current opinion in microbiology · 2010Review
- Heterogeneity in the sensitivity of microtubules of Giardia lamblia to the herbicide oryzalin.Parasitology research · 2010Article
- High-resolution crystal structure and in vivo function of a kinesin-2 homologue in Giardia intestinalis.Molecular biology of the cell · 2008Article
- alpha14-Giardin (annexin E1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella.Parasitology research · 2008Article
- Treatment of giardiasis.Clinical microbiology reviews · 2001Review
- Recognition of a 30,000 MW antigen of Giardia muris trophozoites by intestinal IgA from Giardia-infected mice.Immunology · 1990Article
- Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin.The Journal of cell biology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sheared flagella from Giardia lamblia were freed from cytoskeleton fragments and other cell contaminants by centrifuging in a density gradient. The purified organelles contain many polypeptides, including a set of low-molecular-weight antigens [apparent molecular weights (MWs) = 31, 32, 34, 35 and 37 kD] in the same size range as the approximately 30 kD structural giardins of the cytoskeleton. However, on sodium dodecyl sulphate-polyacrylamide gels, the mobilities of individual flagellar polypeptides do not correspond exactly to the cytoskeleton bands, and, unlike the cytoskeleton proteins, the flagellar components are easily extracted by Triton demembranation. The pattern of flagellar isoforms after isoelectric focussing (IEF) and electrophoresis in two dimensions is also clearly different from that of the cytoskeleton proteins. The fact that at least some approximately 30 kD flagellar antigens are localised by immunofluorescence specifically in the two ventral flagella suggests that these proteins may be components of the paraflagellar structures found beneath the membrane of these organelles. In electron micrographs of the isolated flagella, the paraflagellar rods are seen to bridge the membrane to three adjacent doublet microtubules of the axoneme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.