ArticleInternational journal of geriatric psychiatry2021
A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.
Article in International journal of geriatric psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The Frail Depressed Patient: A Narrative Review on Treatment Challenges.Clinical interventions in aging · 2022Pooled it
- Integrated physical and mental healthcare for older adults in Europe: from concept to implementation-a joint EuGMS and EAGP perspectives paper.European geriatric medicine · 2026Article
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Association Between the Frailty Index and Self-Reported Headache in Middle-Aged and Older Chinese Adults: An Analysis of the China Health and Retirement Longitudinal Study.Pain research & management · 2026Article
- Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.International psychogeriatrics · 2023Article
- Causal relationship between depression and aging: a bidirectional two-sample Mendelian randomization study.Aging clinical and experimental research · 2023Article
- The 'discontinuity hypothesis' of depression in later life-clinical and research implications.Age and ageing · 2023Review
- Depression and Pseudodementia: Decoding the Intricate Bonds in an Italian Outpatient Setting.Brain sciences · 2023Article
- Association of frailty with cognitive impairment and functional disability in older adults with affective disorders: a brief research report.Frontiers in psychiatry · 2023Article
- Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review.Annals of geriatric medicine and research · 2022Article
- Frailty and affective disorders throughout adult life: A 5-year follow-up of the Lifelines Cohort Study.Journal of the American Geriatrics Society · 2022Article
- Article
- A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.International journal of geriatric psychiatry · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDepressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder.
methodsA cohort study with 6-year follow-up including 377 older (≥60 years) outpatients with a DSM-IV-defined depressive disorder and 132 never-depressed controls. Site visits at baseline, 2 and 6-year follow-up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41-item FI was operationalised and validated against the 6-year morality rate by Cox regression (HR
resultsCox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HR
conclusionsThe sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM-IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late-life depression.
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