Evidence map›Paper›PMID 34130255›Full record

ArticleEpilepsy research2021

Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice.

Tanishka S Saraf, Daniel E Felsing, Jessica L Armstrong, Raymond G Booth, Clinton E Canal

Open access · greenAbstract read
In one paragraph

Article in Epilepsy research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Altered brain serotonin 5-HTNeuropharmacology · 2024
    Article
  6. The PsychedelicACS pharmacology & translational science · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tanishka S SarafMercer University, College of Pharmacy, Department of Pharmaceutical Sciences, 3001 Mercer University Drive, Atlanta, GA, 30341, USA. Electronic address: tanishka.satyajit.saraf@live.mercer.edu.
Daniel E FelsingNortheastern University, Center for Drug Discovery, College of Science, Department of Pharmaceutical Sciences, School of Pharmacy, 116 Mugar Hall, 360 Huntington Avenue, Boston, MA, 02115, USA. Electronic address: defelsin@utmb.edu.
Jessica L ArmstrongMercer University, College of Pharmacy, Department of Pharmaceutical Sciences, 3001 Mercer University Drive, Atlanta, GA, 30341, USA. Electronic address: jessica.l.armstrong@live.mercer.edu.
Raymond G BoothNortheastern University, Center for Drug Discovery, College of Science, Department of Pharmaceutical Sciences, School of Pharmacy, 116 Mugar Hall, 360 Huntington Avenue, Boston, MA, 02115, USA. Electronic address: ra.booth@northeastern.edu.
Clinton E CanalMercer University, College of Pharmacy, Department of Pharmaceutical Sciences, 3001 Mercer University Drive, Atlanta, GA, 30341, USA. Electronic address: canal_ce@mercer.edu.
Mercer University · USNortheastern University · US

Funding

Delineating the role of serotonin 5-HT2 receptors in opioid use disorders:Development of novel 5-HT2 modulators with translational studies in rodents andprimatesR01DA047130 · NIDA · NORTHEASTERN UNIVERSITY · PI BOOTH, RAYMOND G., KOHUT, STEPHEN JOHN · 2018 to 2022
$3.2M
Targeting Serotonin 5-HT1A and 5-HT7 Receptors to Prevent Audiogenic Seizures and Correct Translationally Valid EEG Phenotypes in a Juvenile Fmr1 Knock-Out Mouse Model of Fragile X SyndromeR15NS118352 · NINDS · MERCER UNIVERSITY MACON · PI CANAL, CLINTON E · 2020 to 2020
$424k
NIDA NIH HHS R01 DA047130NINDS NIH HHS R15 NS118352
6 · The paper itself

Abstract

Recent preclinical and clinical studies suggest that lorcaserin, a preferential serotonin 2C receptor (5-HT

Indexed as

AnticonvulsantsEpilepsy, ReflexAnimalsBenzazepinesMiceMice, KnockoutAnticonvulsantsBenzazepineslorcaserin5-HT(2A)5-HT(2C)Audiogenic seizuresFmr1 knockout mouseHead-twitch responseLorcaserin

Identifiers

PMID34130255
PMCPMC8296307
OpenAlexW3169876616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.