Evidence map›Paper›PMID 34130185›Full record

ArticleJournal of affective disorders2021

Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring.

Destiny M B Printz Pereira, Damion J Grasso, Colin A Hodgkinson, Kimberly J McCarthy, Lauren S Wakschlag, Margaret J Briggs-Gowan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. The relationship between childhood trauma, rs1360780 genotypes,European journal of psychotraumatology · 2025
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Destiny M B Printz PereiraDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, United States.
Damion J GrassoDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, United States.
Colin A HodgkinsonNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United States.
Kimberly J McCarthyDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, United States.
Lauren S WakschlagDepartment of Medical Social Sciences, Feinberg School of Medicine, and Institute for Innovations in Developmental Sciences Northwestern University, Chicago, IL, United States.
Margaret J Briggs-GowanDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, United States. Electronic address: mbriggsgowan@uchc.edu.
University of Connecticut · USNational Institutes of Health · USNorthwestern University · USUConn Health · US

Funding

Developmental Characterization of Preschool Disruptive BehaviorR01MH082830 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2009 to 2013
$3.7M
Early Traumatic Stress Exposure: Neurodevelopmental Mechanisms of Clinical RiskU01MH090301 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BRIGGS-GOWAN, MARGARET J · 2012 to 2014
$2.4M
NIMH NIH HHS R01 MH082830NIMH NIH HHS U01 MH090301
6 · The paper itself

Abstract

backgroundChildren of parents with posttraumatic stress (PTS) face heightened risk for developing emotional and behavioral problems, regardless of whether they experience a traumatic event themselves. The current study investigates whether child FKBP5, a stress relevant gene shown to interact with child trauma exposure to increase risk for PTS, also moderates the well-established link between maternal PTS and child symptoms.

methodsData are derived from a longitudinal lab-based study for which 205 dyads of trauma-exposed mothers and their preschool-age children from a sample enriched for violence exposure provided DNA samples and completed measures of maternal and child trauma-related symptoms. Hypotheses tested whether child FKBP5 rs1360780 SNP genotype interacts with child trauma exposure and maternal PTS to predict child trauma-related symptoms.

resultsHypotheses were partially supported, with maternal PTS predicting increased child symptoms for children carrying the minor T-allele (CT/TT), but not those homozygous for the major C-allele. LIMITATIONS: Study results may not generalize to lower-risk or non-clinical populations, did not assess between-group differences in race/ethnicity, and do not consider other genes that may interact with FKBP5 or contribute to genetic risk for trauma-related impairment.

conclusionsThese findings provide the first evidence that the robust gene x environment interaction involving FKBP5 and child trauma exposure extends to other environmental perturbations, including maternal PTS. Our results highlight the importance of efforts to address trauma-related psychopathology in caregivers, which may disrupt intergenerational risk processes and improve outcomes for children.

Indexed as

MothersStress Disorders, Post-TraumaticTacrolimus Binding ProteinsAllelesChild, PreschoolFemaleGene-Environment InteractionGenotypeHumansTacrolimus Binding Protein 5Tacrolimus Binding Protein 5Tacrolimus Binding ProteinsDissociationFKBP5Intergenerational traumaPosttraumatic stressPreschoolers

Identifiers

PMID34130185
PMCPMC10112507
OpenAlexW3164406953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.