Evidence map›Paper›PMID 34130111›Full record

ArticleBioorganic chemistry2021

Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment.

Thais Regina Ferreira de Melo, Brian M Dulmovits, Guilherme Felipe Dos Santos Fernandes, Cristiane M de Souza, Carolina Lanaro, Minghzu He, Yousef Al Abed, Man Chin Chung, Lionel Blanc, Fernando Ferreira Costa and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Article
  2. Isoindoline-1,3-dione Derivatives as Prototypes for Anticonvulsant Drug Discovery.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Thais Regina Ferreira de MeloSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.
Brian M DulmovitsDepartment of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA; Laboratory of Developmental Erythropoiesis, Les Nelkin Memorial Pediatric Oncology Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Guilherme Felipe Dos Santos FernandesSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.
Cristiane M de SouzaFaculty of Medical Sciences, State University of Campinas - UNICAMP, Campinas 13083-970, Brazil.
Carolina LanaroFaculty of Medical Sciences, State University of Campinas - UNICAMP, Campinas 13083-970, Brazil.
Minghzu HeDepartment of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA; Laboratory of Developmental Erythropoiesis, Les Nelkin Memorial Pediatric Oncology Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Yousef Al AbedDepartment of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA; Laboratory of Developmental Erythropoiesis, Les Nelkin Memorial Pediatric Oncology Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Man Chin ChungSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.
Lionel BlancDepartment of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.
Fernando Ferreira CostaFaculty of Medical Sciences, State University of Campinas - UNICAMP, Campinas 13083-970, Brazil.
Jean Leandro Dos SantosSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil. Electronic address: jean.santos@unesp.br.
Universidade Estadual Paulista (Unesp) · BRHofstra University · US

Funding

Molecular targeting of erythroid progenitor cells in normal and disordered human erythropoiesisR01HL144436 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI BLANC, LIONEL · 2019 to 2023
$2.5M
NHLBI NIH HHS R01 HL144436
6 · The paper itself

Abstract

Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide-nitric oxide (NO) donor derivatives (3a-f) and evaluated their suitability as novel HbF inducers. All compounds demonstrated different capacities of releasing NO, ranging 0.3-30.3%. Compound 3d was the most effective HbF inducer for CD34

Indexed as

Anemia, Sickle CellDose-Response Relationship, DrugHumansMolecular StructureStructure-Activity RelationshipThalidomidepomalidomideThalidomideEpigeneticsFetal hemoglobin inducersNitric oxideNO-donorsPomalidomideSickle Cell Disease

Identifiers

PMID34130111
PMCPMC8387409
OpenAlexW3168013865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.