Evidence map›Paper›PMID 34129842›Full record

ReviewThe American journal of pathology2021

Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images.

Madeleine S Durkee, Rebecca Abraham, Marcus R Clark, Maryellen L Giger

Abstract readReview
In one paragraph

Review in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Integrating Spatial Proteogenomics in Cancer Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Enhanced Burn Wound Healing and Conversion Prevention Through Inhibition of High Mobility Group Box 1 in a Scald Burn Rat Model.Journal of burn care & research : official publication of the American Burn Association · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. AI-Assisted Cell Culture System.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. [A review on depth perception techniques in organoid images].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madeleine S DurkeeDepartment of Radiology and the Committee on Medical Physics, University of Chicago, Chicago, Illinois. Electronic address: durkeems@uchicago.edu.
Rebecca AbrahamDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois.
Marcus R ClarkDepartment of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois.
Maryellen L GigerDepartment of Radiology and the Committee on Medical Physics, University of Chicago, Chicago, Illinois. Electronic address: m-giger@uchicago.edu.

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
University of Chicago Autoimmunity Center of ExcellenceU19AI082724 · NIAID · UNIVERSITY OF CHICAGO · PI WILSON, PATRICK CHRISTOPHER · 2009 to 2023
$7.2M
Intrarenal B cells in acute kidney allograft rejectionR01AI148705 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S, CLARK, MARCUS RAMSAY · 2020 to 2024
$4.0M
Tertiary Lymphoid Neogenesis in Human Lupus NephritisR01AR055646 · NIAMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2008 to 2018
$3.4M
Quantitative Image Analysis for Assessing Response to Breast Cancer TherapyU01CA195564 · NCI · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2015 to 2019
$2.5M
NCI NIH HHS U01 CA195564NIAID NIH HHS R01 AI148705NIAID NIH HHS U19 AI082724NIAMS NIH HHS R01 AR055646NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

With applications in object detection, image feature extraction, image classification, and image segmentation, artificial intelligence is facilitating high-throughput analysis of image data in a variety of biomedical imaging disciplines, ranging from radiology and pathology to cancer biology and immunology. Specifically, a growth in research on deep learning has led to the widespread application of computer-visualization techniques for analyzing and mining data from biomedical images. The availability of open-source software packages and the development of novel, trainable deep neural network architectures has led to increased accuracy in cell detection and segmentation algorithms. By automating cell segmentation, it is now possible to mine quantifiable cellular and spatio-cellular features from microscopy images, providing insight into the organization of cells in various pathologies. This mini-review provides an overview of the current state of the art in deep learning- and artificial intelligence-based methods of segmentation and data mining of cells in microscopy images of tissue.

Indexed as

Artificial IntelligenceImage Processing, Computer-AssistedMicroscopyOrgan SpecificityAnimalsCellsDeep LearningHumans

Identifiers

PMID34129842
PMCPMC8485056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.