Evidence map›Paper›PMID 34129275›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Discovery of Novel Bacterial Chalcone Isomerases by a Sequence-Structure-Function-Evolution Strategy for Enzymatic Synthesis of (S)-Flavanones.

Hannes Meinert, Dong Yi, Bastian Zirpel, Eva Schuiten, Torsten Geißler, Egon Gross, Stephan I Brückner, Beate Hartmann, Carsten Röttger, Jakob P Ley and 1 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Heterologous activation and metabolites identification of theSynthetic and systems biotechnology · 2024
    Article
  2. Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Structural Basis for (2Molecules (Basel, Switzerland) · 2022
    Article
  5. Discovery of Novel Tyrosine Ammonia Lyases for the Enzymatic Synthesis of p-Coumaric Acid.Chembiochem : a European journal of chemical biology · 2022
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hannes MeinertDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Strasse 4, 17489, Greifswald, Germany.ORCID 0000-0001-6545-5047
Dong YiDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Strasse 4, 17489, Greifswald, Germany.ORCID 0000-0003-2594-0464
Bastian ZirpelSymrise, P.O. Box 1253, 37603, Holzminden, Germany.ORCID 0000-0001-9160-5352
Eva SchuitenDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Strasse 4, 17489, Greifswald, Germany.ORCID 0000-0002-2371-0959
Torsten GeißlerSymrise, P.O. Box 1253, 37603, Holzminden, Germany.ORCID 0000-0001-5281-2324
Egon GrossSymrise, P.O. Box 1253, 37603, Holzminden, Germany.
Stephan I BrücknerSymrise, P.O. Box 1253, 37603, Holzminden, Germany.ORCID 0000-0002-2057-0110
Beate HartmannSymrise, P.O. Box 1253, 37603, Holzminden, Germany.
Carsten RöttgerSymrise, P.O. Box 1253, 37603, Holzminden, Germany.
Jakob P LeySymrise, P.O. Box 1253, 37603, Holzminden, Germany.ORCID 0000-0001-9388-4260
Uwe T BornscheuerDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Strasse 4, 17489, Greifswald, Germany.ORCID 0000-0003-0685-2696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chalcone isomerase (CHI) is a key enzyme in the biosynthesis of flavonoids in plants. The first bacterial CHI (CHI

Indexed as

EubacteriumFlavanonesIntramolecular LyasesMolecular StructureSubstrate Specificitychalcone isomeraseFlavanonesIntramolecular Lyasesbiocatalysischalconechalcone isomeraseflavanoneflavonoid

Identifiers

PMID34129275
PMCPMC8361940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.