Evidence map›Paper›PMID 34129201›Full record

ArticleCurrent medical science2021

Protective Effect of Hydroxysafflor Yellow A against Chronic Mild Stress-induced Memory Impairments by Suppressing Tau Phosphorylation in Mice.

Ying Wang, Qiang Wang, Jun Chen, Li-He Yao, Ni Tang, Zhen-Xiu Jiang, Yu Luo

Abstract read
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In one paragraph

Article in Current medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying WangDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Qiang WangDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Jun ChenDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Li-He YaoDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Ni TangDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Zhen-Xiu JiangDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Yu LuoInstitute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China. luoy@lzu.edu.cn.
Lanzhou University · CNFirst Hospital of Lanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress plays a critical role in the etiology of sporadic Alzheimer's disease (AD). However, there are currently no effective drugs that can target chronic stress to prevent AD. In this study, we explored the neuroprotective effect of hydroxysafflor yellow A (HSYA) against chronic mild stress (CMS)-induced memory impairments in mice and the underlying mechanism. The Morris water maze test showed that HSYA significantly reduced CMS-induced learning and memory impairments in mice. HSYA increased the expression of brain-derived neurotrophic factor (BDNF) and activated downstream tropomyosin-related kinase B (TrkB) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B(Akt)/mammalian target of rapamycin (mTOR) signaling. HSYA decreased the expression of regulator of calcineurin 1-1L (RCAN1-1L) that could promote the activity of glycogen synthase kinase-3β (GSK-3β). HSYA also attenuated tau phosphorylation by inhibiting the activity of GSK-3β and cyclin-dependent kinase-5 (Cdk5). Our data indicated that HSYA has protective effects against CMS-induced BDNF downregulation, tau phosphorylation and memory impairments. HSYA may be a promising therapeutic candidate for AD by targeting chronic stress.

Indexed as

Alzheimer DiseaseAnimalsBrain-Derived Neurotrophic FactorCalcium-Binding ProteinsChalconeDisease Models, AnimalGene Expression RegulationGlycogen Synthase Kinase 3HumansLearning DisabilitiesMembrane GlycoproteinsMemory DisordersMiceMuscle ProteinsNeuroprotective AgentsPhosphatidylinositol 3-KinasesBdnf protein, mouseBrain-Derived Neurotrophic FactorCalcium-Binding ProteinsChalconeDSCR1 protein, mouseGlycogen Synthase Kinase 3hydroxysafflor yellow AMembrane GlycoproteinsmTOR protein, mouseMuscle ProteinsNeuroprotective AgentsNtrk2 protein, mousePhosphatidylinositol 3-KinasesProtein-Tyrosine KinasesQuinonesReceptor, trkBTOR Serine-Threonine KinasesAlzheimer’s diseasebrain-derived neurotrophic factorchronic stresshydroxysafflor yellow Atau phosphorylation

Identifiers

PMID34129201
OpenAlexW3167333720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.