Evidence map›Paper›PMID 34129178›Full record

ArticleLa Radiologia medica2021

TIRADS, SRE and SWE in INDETERMINATE thyroid nodule characterization: Which has better diagnostic performance?

Ilaria Celletti, Daniele Fresilli, Corrado De Vito, Marco Bononi, Sara Cardaccio, Alessia Cozzolino, Cosimo Durante, Giorgio Grani, Gianmarco Grimaldi, Andrea M Isidori and 2 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ilaria CellettiDepartment of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Daniele FresilliDepartment of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Corrado De VitoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Marco BononiDepartment of Surgery "P. Valdoni", Sapienza University of Rome, Rome, Italy.
Sara CardaccioDepartment of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Alessia CozzolinoDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Cosimo DuranteDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Giorgio GraniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Gianmarco GrimaldiDivision of Radiotherapy, University of L'Aquila, L'Aquila, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Vito CantisaniDepartment of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy. vito.cantisani@uniroma1.it.
Sapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess Strain Ratio (SRE) and Shear Wave Elastography (SWE) accuracy alone and with TIRADS classification, for the risk stratification of indeterminate thyroid nodules. MATERIALS AND

methods128 Patients with 128 indeterminate nodules candidates for thyroidectomy underwent preoperative staging neck ultrasound and were classified according to K-TIRADS score. After TIRADS evaluation, semi-quantitative (SRE) and quantitative (SWE expressed in kPa) elastosonography were performed and relative diagnostic performances, alone and in combination, were compared through ROC curves analysis. In order to maximize the SRE and SWE sensitivity and specificity, their cut-off values were calculated using the Liu test. Bonferroni test was used to evaluate statistically significant differences with a p value < 0.05.

resultsSensitivity, specificity, PPV and NPV were, respectively, 71.4%, 82.4%, 62.5%, 87.5% for K-TIRADS baseline US, 85.7%, 94.1%, 85.7%, 94.1% for SRE and 57.1%, 79.4%, 53.3%, 81.8% for SWE (kPa expressed). SRE evaluation showed the best diagnostic accuracy compared to the SWE (kPa expressed) (p < 0.05) and to the K-TIRADS (p > 0.05). The association of SRE with conventional ultrasound with K-TIRADS score increased sensitivity (92.9% vs 71.4%) but decreased the specificity than conventional US alone (76.5% vs 82.4%).

conclusionStrain Elastosonography can be associated with K-TIRADS US examination in the thyroid nodule characterization with indeterminate cytology; in fact, adding the SRE to K-TIRADS assessment significantly increases its sensitivity and negative predictive value. However, further multicenter studies on larger population are warranted.

Indexed as

Elasticity Imaging TechniquesPreoperative CareUltrasonographyAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesRisk AssessmentROC CurveSensitivity and SpecificitySeverity of Illness IndexThyroidectomyElastosonographyShear-wave elastographyStrain-ratio elastographyThyroid noduleTIRADS

Identifiers

PMID34129178
PMCPMC8370962
OpenAlexW3171316589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.