ReviewClinical reviews in allergy & immunology2022
Nickel Hypersensitivity to Atrial Septal Occluders: Smoke Without Fire?
Review in Clinical reviews in allergy & immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Diagnosis and Management of Patients with Patent Foramen Ovale: Current Evidence and Future Perspective.Journal of cardiovascular development and disease · 2026Review
- Percutaneous Closure of Patent Foramen Ovale is Associated With Improvement of Migraine.Reviews in cardiovascular medicine · 2026Article
- Reduced recurrence of atrial fibrillation after cryoballoon ablation in patients with preprocedural patent foramen ovale: a retrospective single-center observational cohort study.Frontiers in cardiovascular medicine · 2026Article
- Management of Patients with Nickel Hypersensitivity Undergoing Patent Foramen Ovale Closure.Journal of clinical medicine · 2025Article
- Sex-Specific Differences in Patients With and Without Nickel Hypersensitivity Undergoing Patent Foramen Ovale Closure.JACC. Advances · 2025Article
- Treatment of patent foramen ovale.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Review
- Biodegradable Pansy® occluder for patent foramen ovale closure: a multicenter, single-arm, prospective study.Frontiers in cardiovascular medicine · 2025Article
- Endovascular Management of Unruptured Cerebral Aneurysms in Patients with Nickel Allergy: Three Cases.Journal of neuroendovascular therapy · 2025Article
- Arrhythmias Following Patent Foramen Ovale Closure: An Unsolved Enigma.Life (Basel, Switzerland) · 2024Review
- Antithrombotic therapy for transcatheter structural heart intervention.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Review
- Patent Foramen Ovale Closure in Special Clinical Situations: More Questions Than Answers?Life (Basel, Switzerland) · 2024Review
- Atrial Fibrillation After Patent Foramen Ovale Closure: Incidence, Pathophysiology, and Management.Journal of the American Heart Association · 2024Review
- Acquired Nail Hypertrophy Due to Nickel Contact Allergy with Dermoscopic findings: A Case Report and Literature Review.Clinical, cosmetic and investigational dermatology · 2024Article
- Dual Antiplatelet Therapy and Cancer; Balancing between Ischemic and Bleeding Risk: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
- Hypersensitivity Reactions to Components of Cardiac Implantable Electronic Devices and Their Treatment: A Systematic Review.Arrhythmia & electrophysiology review · 2023Review
- Current Challenges and Future Directions in Handling Stroke Patients With Patent Foramen Ovale-A Brief Review.Frontiers in neurology · 2022Review
- Analysis of Clinical Features of Kounis Syndrome Induced by Cephalosporin.Frontiers in cardiovascular medicine · 2022Article
- Patent foramen ovale occlusion with the Cocoon PFO Occluder. The PROS-IT collaborative project.Frontiers in cardiovascular medicine · 2022Article
- The management of patent foramen ovale in divers: where do we stand?Therapeutic advances in neurological disorders · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nickel is one of the most common contact allergens worldwide; it is used as the main component of the devices used for atrial septal defects (ASDs) and patent foramen ovale (PFO) closure. Developing nickel hypersensitivity after PFO/ASD occlusion is significantly rarer described in medical literature than typical nickel contact sensitization. The exact pathophysiological mechanism of this "device syndrome" remains unknown, and many question the real incidence or even the existence of this clinical entity. Nevertheless, it has been associated with a wide spectrum of symptoms, including chest pain, migraines, palpitation, and dyspnea. Skin patch tests are the first-line approach to diagnose nickel hypersensitivity. However, diagnostic criteria for the device syndrome have not been developed, and diagnosis in reported cases is established by a process of elimination. Management-drug therapy (corticosteroids, clopidogrel, etc.) or even surgical explantation in severe cases-of patients developing such clinical manifestations after percutaneous PFO/ASD occlusion is empirical. Undoubtedly, endocardiac device-related nickel hypersensitivity requires more focused research to discover the underlying mechanism as well as to develop reliable prognostic tests for detecting high-risk patients and preventing severe nickel hypersensitivity reactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.