Evidence map›Paper›PMID 34129169›Full record

ArticleNeuroinformatics2022

Automated Brain Masking of Fetal Functional MRI with Open Data.

Saige Rutherford, Pascal Sturmfels, Mike Angstadt, Jasmine Hect, Jenna Wiens, Marion I van den Heuvel, Dustin Scheinost, Chandra Sripada, Moriah Thomason

Abstract read
In one paragraph

Article in Neuroinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. [Research Progress in Magnetic Resonance Imaging of Fetal Ventriculomegaly].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  12. Article
  13. Fetal-BET: Brain Extraction Tool for Fetal MRI.IEEE open journal of engineering in medicine and biology · 2024
    Article
  14. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saige RutherfordDonders Institute, Radboud University Medical Center, Nijmegen, The Netherlands. saige.rutherford@donders.ru.nl.ORCID http://orcid.org/0000-0003-3006-9044
Pascal SturmfelsDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.
Mike AngstadtDepartment of Psychiatry, University of Michigan, MI, Ann Arbor, USA.
Jasmine HectDepartment of Psychology, Wayne State University, Detroit, MI, USA.
Jenna WiensDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.
Marion I van den HeuvelDepartment of Cognitive Neuropsychology, University of Tilburg, Tilburg, The Netherlands.
Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Chandra Sripada *Department of Psychiatry, University of Michigan, MI, Ann Arbor, USA.
Moriah Thomason *Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, NY, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
8/24 The Healthy Brain and Child Development National ConsortiumU01DA055338 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Obianuju Berry, Lauren Christine Shuffrey · 2021 to 2026
$9.4M
Examining Prenatal Inflammation and Neurodevelopment in a Longitudinal Fetal-to-Age 9 Imaging Study - Administrative SupplementR01MH122447 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI THOMASON, MORIAH E, TRENTACOSTA, CHRISTOPHER J · 2020 to 2025
$3.9M
“Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child NeurodevelopmentR01MH126468 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRITO, NATALIE HIROMI, THOMASON, MORIAH E · 2021 to 2024
$3.0M
In Utero Assessment of the Human Neural Connectome and Later Child BehaviorR01MH110793 · NIMH · WAYNE STATE UNIVERSITY · PI THOMASON, MORIAH E · 2016 to 2021
$2.7M
From the womb to the classroom: Linking perinatal micronutrients and toxicants to neural and behavioral development in utero and in childhoodR01ES032294 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARTINEZ, MAURO, THOMASON, MORIAH E · 2020 to 2024
$2.6M
4:4 Investigation of opioid exposure and neurodevelopment (iOPEN)R34DA050287 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGINK, VEERLE, THOMASON, MORIAH E · 2019 to 2021
$979k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R34 DA050287NIDA NIH HHS U01 DA055338NIEHS NIH HHS R01 ES032294NIMH NIH HHS R01 MH110793NIMH NIH HHS R01 MH122447NIMH NIH HHS R01 MH126468
6 · The paper itself

Abstract

Fetal resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a critical new approach for characterizing brain development before birth. Despite the rapid and widespread growth of this approach, at present, we lack neuroimaging processing pipelines suited to address the unique challenges inherent in this data type. Here, we solve the most challenging processing step, rapid and accurate isolation of the fetal brain from surrounding tissue across thousands of non-stationary 3D brain volumes. Leveraging our library of 1,241 manually traced fetal fMRI images from 207 fetuses, we trained a Convolutional Neural Network (CNN) that achieved excellent performance across two held-out test sets from separate scanners and populations. Furthermore, we unite the auto-masking model with additional fMRI preprocessing steps from existing software and provide insight into our adaptation of each step. This work represents an initial advancement towards a fully comprehensive, open-source workflow, with openly shared code and data, for fetal functional MRI data preprocessing.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingBrainFetusNeural Networks, ComputerBrain segmentationConvolutional neural networkDeep learningFetalfMRIFunctional imagingOpen-source software

Identifiers

PMID34129169
PMCPMC9437772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.