Evidence map›Paper›PMID 34129128›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Diagnosis and treatment of Chiari malformation and syringomyelia in adults: international consensus document.

Palma Ciaramitaro, Luca Massimi, Alessandro Bertuccio, Alessandra Solari, Mariangela Farinotti, Paola Peretta, Veronica Saletti, Luisa Chiapparini, Andrea Barbanera, Diego Garbossa and 26 more

Erratum issuedAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Intraoperative ultrasonography in the surgical management of Chiari I malformation: A systematic review and meta-analysis of outcomes and applications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  3. The management of Chiari malformation type 1 and syringomyelia in children: a review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  4. Clinical and MRI morphometric characterization of symptomatic cerebellar tonsillar ectopia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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  8. [Imaging assessment and treatment of Charcot arthropathy of the shoulder assisted by NGH classification].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  9. Article
  10. Article
  11. MRI-morphometric characterization of Chiari malformation types 0 and 1 with syringomyelia: implications for diagnosis and pathogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
  12. Article
  13. Natural history of Chiari I malformation-syringomyelia: longitudinal cohort study.Journal of neurology, neurosurgery, and psychiatry · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The Genetics of Chiari 1 Malformation.Journal of clinical medicine · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 18 institutions in 8 countries.

Palma CiaramitaroCRESSC, SSD Coordinamento Neurofisiologia Clinica and Neurosurgery Unit, Department of Neuroscience, University of Torino, Torino, Italy. palma.ciaramitaro@gmail.com.ORCID http://orcid.org/0000-0002-7345-8691
Luca MassimiPediatric Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Alessandro BertuccioDepartment of Neurosurgery, "SS Antonio e Biagio e Cesare Arrigo" Hospital, Alessandria, Italy.
Alessandra SolariNeuroepidemiology Unit - Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Mariangela FarinottiNeuroepidemiology Unit - Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Paola PerettaPediatric Neurosurgery, Ospedale Infantile ReginaMargherita, AOU Citta' della Salute e della Scienza di Torino, Torino, Italy.
Veronica SalettiDevelopmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Luisa ChiappariniDepartment of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Andrea BarbaneraDepartment of Neurosurgery, "SS Antonio e Biagio e Cesare Arrigo" Hospital, Alessandria, Italy.
Diego GarbossaCRESSC, SSD Coordinamento Neurofisiologia Clinica and Neurosurgery Unit, Department of Neuroscience, University of Torino, Torino, Italy.
Paolo BologneseChiari Neuosurgical Center, Mount Sinai, South Nassau, Oceanside, NY, USA.
Andrew BrodbeltConsultant Neurosurgeon, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Carlo CeladaAISMAC, Torino, Italy.
Dario CocitoIstituti Clinici Scientifici Maugeri, Torino, Italy.
Marcella CuroneCasa di Cura del Policlinico, Igea Headache Center, Milan, Italy.
Grazia DevigiliDepartment of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Alessandra ErbettaService of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Marilena FerrarisService of Neuroradiology, Diagnostic Imaging Department, AOU Citta' della Salute e della Scienza di Torino, Torino, Italy.
Marika FurlanettoDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Mado GilantonAPAISER, Treillières, France.
George JalloJohns Hopkins University Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, USA.
Marieta KaradjovaNeurology Department, University of Sofia, Sofia, Bulgaria.
Jorg KlekampChristliches Krankenhaus Quakenbrück, Department of Neurosurgery, Quakenbrück, Germany.
Fulvio MassaroDepartment of Neurosurgery, University of Torino, Torino, Italy.
Sylvia MorarNeurosurgery Department, Reference Center Rares Diseases C-MAVEM, CHU Bicetre APHP, Paris, France.
Fabrice ParkerNeurosurgery Department, Reference Center Rares Diseases C-MAVEM, CHU Bicetre APHP, Paris, France.
Paolo PerriniDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Maria Antonia PocaNeurosurgery and Pediatric Neurosurgery, Vall d'Hebron Hospital Universitari, Neurotrauma and Neurosurgery Research Unit, and Universitat Autònoma de Barcelona, Barcelona, Spain.
Juan SahuquilloNeurosurgery and Pediatric Neurosurgery, Vall d'Hebron Hospital Universitari, Neurotrauma and Neurosurgery Research Unit, and Universitat Autònoma de Barcelona, Barcelona, Spain.
Marcus StoodleyThe Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, 2109, Australia.
Giuseppe TalamontiDepartment of Neurosurgery, ASST Niguarda, Milan, Italy.
Fabio TriulziNeuroradiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy.
Maria Consuelo ValentiniService of Neuroradiology, Diagnostic Imaging Department, AOU Citta' della Salute e della Scienza di Torino, Torino, Italy.
Massimiliano VisocchiDepartment of Neurosurgery, Catholic University School of Medicine, Rome, Italy.
Laura ValentiniDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
International Experts Jury of the Chiari Syringomyelia Consensus Conference, Milan, November 11-13, 2019
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAssistance Publique – Hôpitaux de Paris · FRAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITUniversitat Autònoma de Barcelona · ESUniversity of Turin · ITAgostino Gemelli University Polyclinic · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITDiabetes-Zentrum Quakenbrück · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituti Clinici Scientifici Maugeri · ITJohns Hopkins University · USMacquarie University · AUOspedale Regina Margherita · ITSofia University "St. Kliment Ohridski" · BGUniversità Cattolica del Sacro Cuore · ITUniversity of Liverpool · GBUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSyringomyelia and Chiari malformation are classified as rare diseases on Orphanet, but international guidelines on diagnostic criteria and case definition are missing. AIM OF THE STUDY: to reach a consensus among international experts on controversial issues in diagnosis and treatment of Chiari 1 malformation and syringomyelia in adults.

methodsA multidisciplinary panel of the Chiari and Syringomyelia Consortium (4 neurosurgeons, 2 neurologists, 1 neuroradiologist, 1 pediatric neurologist) appointed an international Jury of experts to elaborate a consensus document. After an evidence-based review and further discussions, 63 draft statements grouped in 4 domains (definition and classification/planning/surgery/isolated syringomyelia) were formulated. A Jury of 32 experts in the field of diagnosis and treatment of Chiari and syringomyelia and patient representatives were invited to take part in a three-round Delphi process. The Jury received a structured questionnaire containing the 63 statements, each to be voted on a 4-point Likert-type scale and commented. Statements with agreement <75% were revised and entered round 2. Round 3 was face-to-face, during the Chiari Consensus Conference (Milan, November 2019).

resultsThirty-one out of 32 Jury members (6 neurologists, 4 neuroradiologists, 19 neurosurgeons, and 2 patient association representatives) participated in the consensus. After round 2, a consensus was reached on 57/63 statements (90.5%). The six difficult statements were revised and voted in round 3, and the whole set of statements was further discussed and approved.

conclusionsThe consensus document consists of 63 statements which benefited from expert discussion and fine-tuning, serving clinicians and researchers following adults with Chiari and syringomyelia.

Indexed as

Arnold-Chiari MalformationSyringomyeliaAdultChildHumansRare DiseasesSurveys and QuestionnairesAdultsChiari malformationClassificationConsensusSurgerySyringomyelia

Identifiers

PMID34129128
OpenAlexW3171537443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.