Evidence map›Paper›PMID 34129096›Full record

ArticleWiener klinische Wochenschrift2021

COVID-19-associated myoclonus in a series of five critically ill patients.

Alexander Grieb, Tamara Seitz, Reinhard Kitzberger, Manfred Schmidbauer, Wolfgang Hoepler, Sebastian Baumgartner, Marianna T Traugott, Erich Pawelka, Mario Karolyi, Georg Strasser and 5 more

Abstract read
In one paragraph

Article in Wiener klinische Wochenschrift, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexander Grieb4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria. alexander.grieb@gmx.at.ORCID http://orcid.org/0000-0001-9449-5144
Tamara Seitz4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Reinhard Kitzberger4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Manfred SchmidbauerHead-Nerve Center, Medical Faculty, Sigmund Freud University, Freudplatz 2, 1020, Vienna, Austria.
Wolfgang Hoepler4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Sebastian Baumgartner4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Marianna T Traugott4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Erich Pawelka4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Mario Karolyi4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Georg Strasser1st Medical Division for Cardiology, Klinik Donaustadt, Langobardenstr. 122, 1220, Vienna, Austria.
Karolina Knibbe1st Medical Division for Cardiology, Klinik Donaustadt, Langobardenstr. 122, 1220, Vienna, Austria.
Hermann Laferl4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Alexander Zoufaly4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Christoph Wenisch4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.
Stephanie Neuhold4th Medical Division for Infectious Disease Medicine and Tropical Medicine, Klinik Favoriten, Pav. C, Kundtratstr. 3, 1100, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn addition to respiratory symptoms, many patients with coronavirus disease 2019 (COVID-19) present with neurological complications. Several case reports and small case series described myoclonus in five patients suffering from the disease. The purpose of this article is to report on five critically ill patients with COVID-19-associated myoclonus. MATERIAL AND

methodsThe clinical courses and test results of patients treated in the study center ICU and those of partner hospitals are described. Imaging, laboratory tests and electrophysiological test results are reviewed and discussed.

resultsIn severe cases of COVID-19 myoclonus can manifest about 3 weeks after initial onset of symptoms. Sedation is sometimes effective for symptom control but impedes respiratory weaning. No viral particles or structural lesions explaining this phenomenon were found in this cohort.

conclusionMyoclonus in patients with severe COVID-19 may be due to an inflammatory process, hypoxia or GABAergic impairment. Most patients received treatment with antiepileptic or anti-inflammatory agents and improved clinically.

Indexed as

COVID-19MyoclonusCritical IllnessHumansIntensive Care UnitsSARS-CoV-2Case seriesIntensive careMovement disordersSARS-CoV‑2Sedation

Identifiers

PMID34129096
PMCPMC8204731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.