ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2022
β-Adrenergic blockade in patients with dementia and hip fracture is associated with decreased postoperative mortality.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- High variability in patient reported outcome utilization following hip fracture: a potential barrier to value-based care.Archives of osteoporosis · 2021Pooled it
- The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis.Aging clinical and experimental research · 2021Pooled it
- The relationship and predictive value of dementia and frailty for mortality in patients with surgically managed hip fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- The mortality burden of frailty in hip fracture patients: a nationwide retrospective study of cause-specific mortality.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Dementia is a surrogate for frailty in hip fracture mortality prediction.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- β-Adrenergic blockade in patients with dementia and hip fracture is associated with decreased postoperative mortality.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Early Detection of Pneumonia with the Help of Dementia in Geriatric Hip Fracture Patients.Orthopaedic surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDementia, present in 20% of hip fracture patients, is associated with an almost threefold increase in postoperative mortality risk. These patients have a substantially higher incidence of cardiovascular, respiratory, and cerebrovascular mortality after hip fracture surgery compared to patients without dementia. This study aimed to investigate the association between beta-blocker therapy and postoperative mortality in patients with dementia undergoing hip fracture surgery.
methodsThis nationwide study included all patients in Sweden with the diagnosis of dementia who underwent emergency surgery for a hip fracture between January 2008 and December 2017. Cases where the hip fracture was pathological or conservatively managed were not included. Poisson regression analysis with robust standard errors was performed while controlling for confounders to determine the relationship between beta-blocker therapy and all-cause, as well as cause-specific, postoperative mortality.
resultsA total of 26,549 patients met the study inclusion criteria, of whom 8258 (31%) had ongoing beta-blocker therapy at time of admission. After adjusting for clinically relevant variables, the incidence of postoperative mortality in patients receiving beta-blocker therapy was decreased by 50% at 30 days [adj. IRR (95% CI) 0.50 (0.45-0.54), p < 0.001] and 34% at 90 days [adj. IRR (95% CI) 0.66 (0.62-0.70), p < 0.001]. Cause-specific mortality analysis demonstrated a significant reduction in the incidence of postoperative cardiovascular, respiratory, and cerebrovascular death within 30 and 90 days postoperatively.
conclusionBeta-blocker therapy is associated with decreased postoperative mortality in hip fracture patients with dementia up to 90 days after surgery. This finding warrants further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.