ArticleThe Journal of cell biology2021
A global chromatin compaction pathway that represses germline gene expression during starvation.
Article in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- An atlas of thebioRxiv : the preprint server for biology · 2026Article
- Nutrient-responsive and DAF-16/FoxO target H1 histone HIL-1 promotes resistance to starvation and bacterial pathogens inbioRxiv : the preprint server for biology · 2026Article
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- Article
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA.bioRxiv : the preprint server for biology · 2024Article
- The TOP-2/condensin II axis silences transcription during germline specification in C. elegans.G3 (Bethesda, Md.) · 2024Article
- ZIF-1-mediated degradation of zinc finger proteins in the Caenorhabditis elegans germ line.Genetics · 2023Article
- Article
- ZIF-1-mediated degradation of endogenous and heterologous zinc finger proteins in thebioRxiv : the preprint server for biology · 2023Article
- Characterization of factors that underlie transcriptional silencing in C. elegans oocytes.PLoS genetics · 2023Article
- The Embryonic Origin of Primordial Germ Cells in the TardigradebioRxiv : the preprint server for biology · 2023Article
- Transcriptional repression during spermatogenesis inmicroPublication biology · 2023Article
- Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest.Cell reports · 2022Article
- Hatched and starved: Two chromatin compaction mechanisms join forces to silence germ cell genome.The Journal of cell biology · 2021Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
While much is known about how transcription is controlled at individual genes, comparatively little is known about how cells regulate gene expression on a genome-wide level. Here, we identify a molecular pathway in the C. elegans germline that controls transcription globally in response to nutritional stress. We report that when embryos hatch into L1 larvae, they sense the nutritional status of their environment, and if food is unavailable, they repress gene expression via a global chromatin compaction (GCC) pathway. GCC is triggered by the energy-sensing kinase AMPK and is mediated by a novel mechanism that involves the topoisomerase II/condensin II axis acting upstream of heterochromatin assembly. When the GCC pathway is inactivated, then transcription persists during starvation. These results define a new mode of whole-genome control of transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.