Evidence map›Paper›PMID 34128951›Full record

SynthesisCardiovascular journal of Africa

Dietary intakes of green leafy vegetables and incidence of cardiovascular diseases.

Akin Ojagbemi, Akinkunmi Paul Okekunle, Paul Olowoyo, Onoja Matthew Akpa, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Cardiovascular journal of Africa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akin OjagbemiDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Akinkunmi Paul OkekunleDepartment of Medicine, College of Medicine, University of Ibadan; University College Hospital, Ibadan, Nigeria; Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria; Epidemiology Laboratory, Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea.
Paul OlowoyoCollege of Medicine and Health Sciences, Afe Babalola University; Department of Medicine, Federal Teaching Hospital, Ado-Ekiti, Nigeria.
Onoja Matthew AkpaDepartment of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria; Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Rufus AkinyemiCentre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria; Institute of Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Bruce OvbiageleWeill Institute for Neurosciences; School of Medicine, University of California, San Francisco, California, USA.
Mayowa OwolabiDepartment of Medicine, College of Medicine, University of Ibadan; University College Hospital, Ibadan, Nigeria; Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria; Department of Medicine, College of Medicine, University of Ibadan; University College Hospital; Blossom Specialist Medical Centre, Ibadan, Nigeria. Email: mayowaowolabi@yahoo.com.

Funding

H3Africa Administrative Coordinating Centre: Enabling and Supporting Genomics and Health Research Capacity Building in AfricaU24HG009780 · NHGRI · UNIVERSITY OF CAPE TOWN · PI SKELTON, MICHELLE · 2017 to 2022
$4.8M
Stroke Investigative Research & Educational Network (SIREN)U54HG007479 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2013 to 2017
$4.2M
Phone-based Interventions under Nurse Guidance after Stroke II (PINGS II)R01HL152188 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI OVBIAGELE, BRUCE, SARFO, FRED STEPHEN · 2020 to 2024
$2.8M
African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES)R01NS115944 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2020 to 2025
$2.2M
Systematic Investigation of Blacks with Stroke - Genomics (SIBS-Genomics) StudyR01NS107900 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2018 to 2021
$1.8M
NHGRI NIH HHS U24 HG009780NHGRI NIH HHS U54 HG007479NHLBI NIH HHS R01 HL152188NINDS NIH HHS R01 NS107900NINDS NIH HHS R01 NS115944
6 · The paper itself

Abstract

aimLow- and middle-income countries (LMICs) are currently experiencing increasing cardiovascular disease (CVD) rates. Green leafy vegetables (GLV), which are abundant in these countries, are known to be particularly rich in cardioprotective nutrients. This study sought to determine the specific effect of GLV intake on the incidence of CVD.

methodsPreviously published cohort studies on GLV intake and incidence of CVD were retrieved through a systematic search of Google Scholar, EMBASE, MEDLINE, HINARI and Cochrane Library. A methodological evaluation of studies was carried out using the network of Ottawa scale, and a fixed-effect meta-analysis was applied to estimate pooled relative risk (RR) and 95% confidence interval (CI). Heterogeneity was determined using the I

resultsThe pooled RR (95% CI) of incident CVD events from 17 studies was 0.93 (0.92-0.95). Specifically, GLV intake was inversely related with incident cerebral infarction (RR: 0.92; 95% CI: 0.88-0.96), heart disease (RR: 0.93; 95% CI: 0.87-0.99) and other CVD events (RR: 0.95; 95% CI: 0.93-0.98).

conclusionsGLV intake was associated with a lower incidence of CVD, and may be a promising primary-prevention strategy against CVD events. The findings are especially important in LMICs where the burden of CVD remains high.

Indexed as

Primary PreventionVegetablesCardiovascular DiseasesEatingHumansIncidencecardiovascular diseasescerebral infarctioncoronary heart diseasegreen leafy vegetablesheart diseasemeta‐analysis

Identifiers

PMID34128951
PMCPMC8756059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.