Evidence map›Paper›PMID 34128785›Full record

ArticleMicrobial genomics2021

Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations.

Haleluya Wami, Alexander Wallenstein, Daniel Sauer, Monika Stoll, Rudolf von Bünau, Eric Oswald, Rolf Müller, Ulrich Dobrindt

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  9. Contribution of pks+Microorganisms · 2024
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  13. Targeted depletion ofmSystems · 2023
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  14. Genomic and clinical characterization ofFrontiers in microbiology · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Cyclomodulins and Hemolysis inLife (Basel, Switzerland) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Haleluya WamiInstitute of Hygiene, University of Münster, Münster, Germany.
Alexander WallensteinInstitute of Hygiene, University of Münster, Münster, Germany.
Daniel SauerDepartment of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, Saarland University, Campus E8 1, Saarbrücken, Germany.
Monika StollDepartment of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
Rudolf von BünauArdeypharm GmbH, Herdecke, Germany.
Eric OswaldIRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.
Rolf MüllerDepartment of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, Saarland University, Campus E8 1, Saarbrücken, Germany.
Ulrich DobrindtInstitute of Hygiene, University of Münster, Münster, Germany.
University of Münster · DEHelmholtz Institute for Pharmaceutical Research Saarland · DEArdeypharm (Germany) · DEUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bacterial genotoxin colibactin interferes with the eukaryotic cell cycle by causing dsDNA breaks. It has been linked to bacterially induced colorectal cancer in humans. Colibactin is encoded by a 54 kb genomic region in

Indexed as

Secondary MetabolismCitrobacterEnterobacteriaceaeEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGene Transfer, HorizontalHumansKlebsiellaMutagensPeptidesPhenolsPolyketidesThiazolescolibactinEscherichia coli ProteinsMutagensPeptidesPhenolsPolyketidesThiazolesyersiniabactinCitrobactercytopathic effectEscherichia colihigh pathogenicity islandKlebsiellapolyketidesecondary metabolite

Identifiers

PMID34128785
PMCPMC8461471
OpenAlexW3171832340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.