Evidence map›Paper›PMID 34128724›Full record

ArticleRadiology2021

Free-breathing Accelerated Cardiac MRI Using Deep Learning: Validation in Children and Young Adults.

Evan J Zucker, Christopher M Sandino, Aya Kino, Peng Lai, Shreyas S Vasanawala

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 69 citations in OpenAlex.

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  9. Reference ranges for myocardial native T1, T2, and extracellular volume at 5.0T cardiac magnetic resonance imaging in healthy adults.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Evan J ZuckerFrom the Department of Radiology, Stanford University School of Medicine, 725 Welch Rd, Stanford, CA 94305 (E.J.Z., A.K., S.S.V.); Department of Electrical Engineering, Stanford University, Stanford, Calif (C.M.S.); and Global MR Applications and Workflow, GE Healthcare, Menlo Park, Calif (P.L.).ORCID 0000-0002-0667-6322
Christopher M SandinoFrom the Department of Radiology, Stanford University School of Medicine, 725 Welch Rd, Stanford, CA 94305 (E.J.Z., A.K., S.S.V.); Department of Electrical Engineering, Stanford University, Stanford, Calif (C.M.S.); and Global MR Applications and Workflow, GE Healthcare, Menlo Park, Calif (P.L.).ORCID 0000-0002-8360-0153
Aya KinoFrom the Department of Radiology, Stanford University School of Medicine, 725 Welch Rd, Stanford, CA 94305 (E.J.Z., A.K., S.S.V.); Department of Electrical Engineering, Stanford University, Stanford, Calif (C.M.S.); and Global MR Applications and Workflow, GE Healthcare, Menlo Park, Calif (P.L.).
Peng LaiFrom the Department of Radiology, Stanford University School of Medicine, 725 Welch Rd, Stanford, CA 94305 (E.J.Z., A.K., S.S.V.); Department of Electrical Engineering, Stanford University, Stanford, Calif (C.M.S.); and Global MR Applications and Workflow, GE Healthcare, Menlo Park, Calif (P.L.).ORCID 0000-0002-6133-5723
Shreyas S VasanawalaFrom the Department of Radiology, Stanford University School of Medicine, 725 Welch Rd, Stanford, CA 94305 (E.J.Z., A.K., S.S.V.); Department of Electrical Engineering, Stanford University, Stanford, Calif (C.M.S.); and Global MR Applications and Workflow, GE Healthcare, Menlo Park, Calif (P.L.).ORCID 0000-0002-1999-6595
Stanford University · US

Funding

Rapid Robust Pediatric MRIR01EB009690 · NIBIB · STANFORD UNIVERSITY · PI LUSTIG, MICHAEL, VASANAWALA, SHREYAS S · 2010 to 2021
$5.6M
Development and Translation of High Performance Receive Arrays for Pediatric MRIR01EB019241 · NIBIB · STANFORD UNIVERSITY · PI PAULY, JOHN M., VASANAWALA, SHREYAS S · 2014 to 2018
$5.6M
NIBIB NIH HHS R01 EB009690NIBIB NIH HHS R01 EB019241
6 · The paper itself

Abstract

Background Obtaining ventricular volumetry and mass is key to most cardiac MRI but challenged by long multibreath-hold acquisitions. Purpose To assess the image quality and performance of a highly accelerated, free-breathing, two-dimensional cine cardiac MRI sequence incorporating deep learning (DL) reconstruction compared with reference standard balanced steady-state free precession (bSSFP). Materials and Methods A DL algorithm was developed to reconstruct custom 12-fold accelerated bSSFP cardiac MRI cine images from coil sensitivity maps using 15 iterations of separable three-dimensional convolutions and data consistency steps. The model was trained, validated, and internally tested in 10, two, and 10 adult human volunteers, respectively, based on vendor partner-supplied fully sampled bSSFP acquisitions. For prospective external clinical validation, consecutive children and young adults undergoing cardiac MRI from September through December 2019 at a single children's hospital underwent both conventional and highly accelerated short-axis bSSFP cine acquisitions in one MRI examination. Two radiologists scored overall and volumetric three-dimensional mesh image quality of all short-axis stacks on a five-point Likert scale and manually segmented endocardial and epicardial contours. Scan times and image quality were compared using the Wilcoxon rank sum test. Measurement agreement was assessed with intraclass correlation coefficient and Bland-Altman analysis. Results Fifty participants (mean age, 16 years ± 4 [standard deviation]; range, 5-30 years; 29 men) were evaluated. The mean prescribed acquisition times of accelerated scans (non-breath-held) and bSSFP (excluding breath-hold time) were 0.9 minute ± 0.3 versus 3.0 minutes ± 1.9 (

Indexed as

Deep LearningAdolescentAdultCardiovascular DiseasesChildChild, PreschoolFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineMaleRespiration

Identifiers

PMID34128724
PMCPMC8409103
OpenAlexW3172950632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.