SynthesisClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2021
ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.
Synthesis in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Advances in the Association Between theCurrent issues in molecular biology · 2026Review
- A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra-Long-Acting βPharmacology research & perspectives · 2025Article
- Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights fromCells · 2024Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Transcription Factor E2F1 Regulates the Expression of ADRB2.International journal of analytical chemistry · 2023Article
- Visualizing the knowledge domains and research trends of childhood asthma: A scientometric analysis with CiteSpace.Frontiers in pediatrics · 2022Article
- Asthma management and impact on COVID-19 outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
Corrections and comments
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Authors and funding
24 authors at 11 institutions in 8 countries.
Funding
Abstract
backgroundThe polymorphism Arg16 in β
objectiveWe assessed whether the haplotype analysis could explain the association between the polymorphisms at codons 16 (Arg16Gly) and 27 (Gln27Glu) in ADRB2 and risk of asthma exacerbations in patients treated with inhaled corticosteroids (ICS) plus LABA.
methodsThe study was undertaken using data from 10 independent studies (n = 5903) participating in the multi-ethnic Pharmacogenomics in Childhood Asthma (PiCA) consortium. Asthma exacerbations were defined as asthma-related use of oral corticosteroids or hospitalizations/emergency department visits in the past 6 or 12 months prior to the study visit/enrolment. The association between the haplotypes and the risk of asthma exacerbations was performed per study using haplo.stats package adjusted for age and sex. Results were meta-analysed using the inverse variance weighting method assuming random-effects.
resultsIn subjects treated with ICS and LABA (n = 832, age: 3-21 years), Arg16/Gln27 versus Gly16/Glu27 (OR: 1.40, 95% CI: 1.05-1.87, I CONCLUSION AND CLINICAL RELEVANCE: The ADRB2 Arg16 haplotype, presumably mainly driven by the Arg16, increased the risk of asthma exacerbations in patients treated with ICS plus LABA. This finding could be beneficial in ADRB2 genotype-guided treatment which might improve clinical outcomes in asthmatic patients.
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Registered trials
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