Evidence map›Paper›PMID 34128246›Full record

ReviewMass spectrometry reviews2023

Recent advances (2019-2021) of capillary electrophoresis-mass spectrometry for multilevel proteomics.

Daoyang Chen, Elijah N McCool, Zhichang Yang, Xiaojing Shen, Rachele A Lubeckyj, Tian Xu, Qianjie Wang, Liangliang Sun

Abstract readReview
In one paragraph

Review in Mass spectrometry reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. A Draft Map of E. coli Proteoforms.Analytical chemistry · 2026
    Article
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  6. Review
  7. Review
  8. Article
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  10. Article
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  13. Capillary Electrophoresis-Mass Spectrometry for Top-Down Proteomics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Native Proteomics by Capillary Zone Electrophoresis-Mass Spectrometry.Angewandte Chemie (International ed. in English) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daoyang ChenDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Elijah N McCoolDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Zhichang YangDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Xiaojing ShenDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Rachele A LubeckyjDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Tian XuDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Qianjie WangDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.
Liangliang SunDepartment of Chemistry, Michigan State University, East Lansing, Michigan, USA.

Funding

Computational tools for top down mass spectrometry based proteoform identification and proteogenomicsR01GM118470 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Xiaowen Liu · 2016 to 2026
$2.7M
Quantitative top-down proteomics of human colorectal cancer cells and tumorsR01CA247863 · NCI · MICHIGAN STATE UNIVERSITY · PI HUMMON, AMANDA B., LIU, XIAOWEN · 2021 to 2025
$1.9M
Quantitative proteomics of Zebrafish embryos and blastomeresR01GM125991 · NIGMS · MICHIGAN STATE UNIVERSITY · PI SUN, LIANGLIANG · 2018 to 2022
$1.7M
NCI NIH HHS R01 CA247863NIGMS NIH HHS R01 GM118470NIGMS NIH HHS R01 GM125991
6 · The paper itself

Abstract

Multilevel proteomics aims to delineate proteins at the peptide (bottom-up proteomics), proteoform (top-down proteomics), and protein complex (native proteomics) levels. Capillary electrophoresis-mass spectrometry (CE-MS) can achieve highly efficient separation and highly sensitive detection of complex mixtures of peptides, proteoforms, and even protein complexes because of its substantial technical progress. CE-MS has become a valuable alternative to the routinely used liquid chromatography-mass spectrometry for multilevel proteomics. This review summarizes the most recent (2019-2021) advances of CE-MS for multilevel proteomics regarding technological progress and biological applications. We also provide brief perspectives on CE-MS for multilevel proteomics at the end, highlighting some future directions and potential challenges.

Indexed as

ProteinsProteomicsElectrophoresis, CapillaryMass SpectrometryPeptidesPeptidesProteinscapillary isoelectric focusing-mass spectrometrycapillary zone electrophoresis-mass spectrometrymultilevel proteomicsprotein complexproteoform

Identifiers

PMID34128246
PMCPMC8671558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.