Evidence map›Paper›PMID 34128180›Full record

ArticleJournal of cardiovascular translational research2022

Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems.

Farhad R Nezami, Mehdi Ramezanpour, Farhan Khodaee, Efrat Goffer, Elazer R Edelman, Steven P Keller

Open access · greenAbstract read
In one paragraph

Article in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Farhad R NezamiInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mehdi RamezanpourDepartment of Mechanical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Farhan KhodaeeInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Efrat GofferInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Elazer R EdelmanInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Steven P KellerInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. spkeller@mit.edu.ORCID 0000-0002-3870-9811
Brigham and Women's Hospital · USMassachusetts Institute of Technology · USUniversity of Pittsburgh · US

Funding

Vascular Drug Delivery - Supplement for EquipmentR01GM049039 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EDELMAN, ELAZER R · 1994 to 2019
$8.9M
Functional restoration of ventriculo-arterial coupling in cardiogenic shock via dual mechanical supportK08HL143342 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KELLER, STEVEN PAUL · 2018 to 2023
$853k
NHLBI NIH HHS 5K08HL14332NHLBI NIH HHS K08 HL143342NIGMS NIH HHS R01 GM049039NIH HHS R0149039
6 · The paper itself

Abstract

Extracorporeal membrane oxygenation (ECMO) is a vital mechanical circulatory support modality capable of restoring perfusion for the patient in circulatory failure. Despite increasing adoption of ECMO, there is incomplete understanding of its effects on systemic hemodynamics and how the vasculature responds to varying levels of continuous retrograde perfusion. To gain further insight into the complex ECMO:failing heart circulation, computational fluid dynamics simulations focused on perfusion distribution and hemodynamic flow patterns were conducted using a patient-derived aorta geometry. Three case scenarios were simulated: (1) healthy control; (2) 90% ECMO-derived perfusion to model profound heart failure; and, (3) 50% ECMO-derived perfusion to model the recovering heart. Fluid-structure interface simulations were performed to quantify systemic pressure and vascular deformation throughout the aorta over the cardiac cycle. ECMO support alters pressure distribution while decreasing shear stress. Insights derived from computational modeling may lead to better understanding of ECMO support and improved patient outcomes.

Indexed as

Extracorporeal Membrane OxygenationAortaComputer SimulationHemodynamicsHumansHydrodynamicsComputational fluid dynamicsExtracorporeal membrane oxygenationFluid-structure interactionMechanical circulatory support

Identifiers

PMID34128180
PMCPMC11694477
OpenAlexW3167792094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.