Evidence map›Paper›PMID 34128105›Full record

ArticleOdontology2021

Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis.

Yoko Yamaguchi, Akira Saito, Masafumi Horie, Akira Aoki, Patrick Micke, Mitsuhiro Ohshima, Kai Kappert

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Odontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Yoko YamaguchiDepartment of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan.
Akira SaitoDepartment of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masafumi HorieDepartment of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Akira AokiDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Patrick MickeDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden. patrick.micke@igp.uu.se.ORCID http://orcid.org/0000-0003-1210-5961
Mitsuhiro OhshimaDepartment of Biochemistry, Ohu University School of Pharmaceutical Sciences, Koriyama, Fukushima, Japan.
Kai KappertCharité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Augustenburger Platz 1, 13353, Berlin, Germany.
Humboldt-Universität zu Berlin · DENihon University · JPOhu University · JPThe University of Osaka · JPThe University of Tokyo · JPTokyo Medical and Dental University · JPUppsala University · SE

Funding

KAKENHI #20K07344
6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease leading to progressive connective tissue degradation and loss of the tooth-supporting bone. Clinical and experimental studies suggest that hepatocyte growth factor (HGF) is involved in the dysregulated fibroblast-epithelial cell interactions in periodontitis. The aim of this study was to explore effects of HGF to impact fibroblast-induced collagen degradation. A patient-derived experimental cell culture model of periodontitis was applied. Primary human epithelial cells and fibroblasts isolated from periodontitis-affected gingiva were co-cultured in a three-dimensional collagen gel. The effects of HGF neutralizing antibody on collagen gel degradation were tested and transcriptome analyses were performed. HGF neutralizing antibody attenuated collagen degradation and elicited expression changes of genes related to extracellular matrix (ECM) and cell adhesion, indicating that HGF signaling inhibition leads to extensive impact on cell-cell and cell-ECM interactions. Our study highlights a potential role of HGF in periodontitis. Antagonizing HGF signaling by a neutralizing antibody may represent a novel approach for periodontitis treatment.

Indexed as

Hepatocyte Growth FactorPeriodontitisFibroblastsGingivaHumansModels, TheoreticalHepatocyte Growth FactorHGF protein, humanExtracellular matrixHepatocyte growth factorHuman primary cellPeriodontitisTranscriptome

Identifiers

PMID34128105
PMCPMC8387255
OpenAlexW3169335089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.