Evidence map›Paper›PMID 34128094›Full record

ArticlePediatric nephrology (Berlin, Germany)2021

Returning to dialysis after kidney allograft failure: the experience of the Italian Registry of Paediatric Chronic Dialysis.

Edoardo La Porta, Ester Conversano, Daniela Zugna, Roberta Camilla, Raffaella Labbadia, Fabio Paglialonga, Mattia Parolin, Enrico Vidal, Enrico Verrina, Italian Registry of Paediatric Chronic Dialysis

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Edoardo La Porta *Dialysis Unit, Department of Pediatrics, IRCCS Giannina Gaslini, Genova, Italy.
Ester Conversano *Department of Pediatrics, Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
Daniela ZugnaDepartment of Medical Sciences, Cancer Epidemiology Unit, University of Torino and CPO-Piemonte, Turin, Italy.
Roberta CamillaPaediatric Nephrology Unit, Regina Margherita Children's Hospital, CDSS, Turin, Italy.
Raffaella LabbadiaNephrology and Dialysis Unit, Department of Pediatrics, "Bambino Gesù" Children's Hospital-IRCCS, Rome, Italy.
Fabio PaglialongaPediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Mattia ParolinPediatric Nephrology, Dialysis and Transplant Unit, Department of Woman's and Child's Health, University Hospital, Padova, Padua, Italy.
Enrico Vidal *Division of Pediatrics, Department of Medicine (DAME), University of Udine, P.le S.M della Misericordia, 15 33100, Udine, Italy. enrico.vidal@inwind.it.ORCID http://orcid.org/0000-0003-3963-0803
Enrico Verrina *Dialysis Unit, Department of Pediatrics, IRCCS Giannina Gaslini, Genova, Italy.
Italian Registry of Paediatric Chronic Dialysis
Istituto Giannina Gaslini · ITBambino Gesù Children's Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIRCCS Materno Infantile Burlo Garofolo · ITOspedale Regina Margherita · ITPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUniversity of Padua · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe need for dialysis after kidney allograft failure (DAGF) is among the top five reasons for dialysis initiation, making this an important topic in clinical nephrology. However, data are scarce on dialysis choice after transplantation and clinical outcomes for DAGF in children.

methodsPatients receiving chronic dialysis < 18 years were recorded from January 1991 to January 2019 by the Italian Registry of Pediatric Chronic Dialysis (IRPCD). We investigated factors influencing choice of dialysis modality, patient outcome in terms of mortality, switching dialysis modality, and kidney transplantation.

resultsAmong 118 patients receiving DAGF, 41 (35%) were treated with peritoneal dialysis (PD), and 77 (65%) with haemodialysis (HD). Significant predictors for treatment with PD were younger age at dialysis start (OR 0.85 per year increase [95%CI 0.72-1.00]) and PD use before kidney transplantation (OR 8.20 [95%CI 1.82-37.01]). Patients entering DAGF in more recent eras (OR 0.87 per year increase [95%CI 0.80-0.94]) and with more than one dialysis modality before kidney transplantation (OR 0.56 for being treated with PD [0.12-2.59]) were more likely to be initiated on HD. As compared to patients on HD, those treated with PD exhibited increased but non-significant mortality risk (HR 2.15 [95%CI 0.54-8.6]; p = 0.28) and higher prevalence of dialysis-related complications during DAGF (p = 0.002)

conclusionsPatients entering DAGF in more recent years are more likely to be initiated on HD. In this specific population of children, use of PD seems associated with a more complicated course. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Kidney Failure, ChronicKidney TransplantationPrimary Graft DysfunctionRenal DialysisAllograftsChildHumansItalyRegistriesComplicationsDeathKidney allograft failureKidney transplantationPaediatric dialysis

Identifiers

PMID34128094
PMCPMC8599402
OpenAlexW3167493160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.