ArticleResearch square2021
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.
David Hafler, Tomokazu Sumida, Shai Dulberg, Jonas Schupp, Helen Stillwell, Pierre-Paul Axisa, Michela Comi, Matthew Lincoln, Avraham Unterman, Naftali Kaminski and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 8 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors at 1 institution in 2 countries.
David HaflerYale University.
Shai DulbergTel Aviv University.
Jonas SchuppYale University.
Helen StillwellYale University.
Pierre-Paul AxisaYale University.
Michela ComiDepartment of Immunobiology, Yale University School of Medicine; Department of Neurology, Yale University School of Medicine.
Avraham UntermanSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine.
Asaf MadiTel Aviv University.
Vijay KuchrooHarvard University.
Tel Aviv University · IL
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MRole of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI VIJAY K. KUCHROO · 1996 to 2026
$51.7MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4MYale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5MTransgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI HAFLER, DAVID A. · 2008 to 2019
$17.1MA Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseUM1HG009390 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2017 to 2021
$11.0MGenomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9MRole of Th1 specific cell surface molecule Tim-3 in EAE.R01NS045937 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2003 to 2016
$4.9MT CELL RESPONSE TO MYELIN PROTEOLIPID PROTEINR01NS030843 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 1998 to 2019
$4.1MEpithelial Protective Effects of Thyroid Hormone Signaling in FibrosisR01HL141852 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$3.4M(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2MNCATS NIH HHS UL1 TR001863NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA227473NHGRI NIH HHS UM1 HG009390NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL141852NHLBI NIH HHS U01 HL145567NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI073748NIAID NIH HHS R01 AI144166NIAID NIH HHS U19 AI089992NINDS NIH HHS R01 NS030843NINDS NIH HHS R01 NS045937NINDS NIH HHS R25 NS079193
6 · The paper itselfAbstract
While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Type 1 interferon (IFN-I) modulates T cell immunity in viral infection, autoimmunity, and cancer, and may facilitate induction of T cell exhaustion in chronic viral infection. Here we show that IFN-I regulates co-inhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while surprisingly inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses enabled the construction of dynamic transcriptional regulatory networks uncovering three temporal transcriptional waves. Perturbation of key transcription factors on human primary T cells revealed unique regulators that control expression of co-inhibitory receptors. We found that the dynamic IFN-I response
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PMID34127967
PMCPMC8202434
OpenAlexW3171664093
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