ArticleResearch square2021
Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
Jason Roh, Robert Kitchen, J Sawalla Guseh, Jenna McNeill, Malika Aid, Amanda Martinot, Andy Yu, Colin Platt, James Rhee, Brittany Weber and 12 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 12 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
22 authors at 2 institutions in 2 countries.
Jason RohHarvard Medical School.
J Sawalla GusehMassachusetts General Hospital.
Jenna McNeillMassachusetts General Hospital.
Malika AidBeth Israel Deaconess Medical Center BIDMC.
Andy YuMassachusetts General Hospital.
Colin PlattMassachusetts General Hospital.
James RheeMassachusetts General Hospital.
Brittany WeberBrigham and Women's Hospital.
Lena TragerMassachusetts General Hospital.
Margaret HastingsMassachusetts General Hospital.
Peng XiaMassachusetts General Hospital.
Claire CastroMassachusetts General Hospital.
Bjarni AtlasonMassachusetts General Hospital.
Timothy ChurchillMassachusetts General Hospital.
Marcelo Di CarliBrigham and Women's Hospital.
Jennifer HoMassachusetts General Hospital.
Anthony RosenzweigMassachusetts General Hospital.
Broad Institute · USHadassah Medical Center · IL
Funding
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MNoninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8MAFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1MEicosanoid Profiles as Determinants of HFpEFR01HL140224 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2018 to 2021
$3.1MRole of Activin Type II receptor signaling in age-related heart failureR01AG061034 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSENZWEIG, ANTHONY · 2019 to 2023
$3.0MThe Association of Metabolic Disease and Pulmonary HypertensionR01HL134893 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2017 to 2021
$2.9MMentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2MActivin type II receptor activity in age-related frailty and heart failureK76AG064328 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI ROH, JASON DAVID · 2019 to 2022
$972kThe Role of Family with Sequence Similarity 3D (FAM3D) in Cardioprotection and Inflammation after Myocardial InfarctionK08HL140200 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RHEE, JAMES · 2019 to 2023
$864kMentoring in Patient-Oriented and Translational HFpEF ResearchK24HL153669 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jennifer E Ho · 2020 to 2026
$744kNHLBI NIH HHS K08 HL140200NHLBI NIH HHS K24 HL105780NHLBI NIH HHS K24 HL153669NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL140224NHLBI NIH HHS T32 HL007208NHLBI NIH HHS T32 HL094301NIA NIH HHS K76 AG064328NIA NIH HHS R01 AG061034
6 · The paper itselfAbstract
Cardiovascular complications are common in COVID-19 and strongly associated with disease severity and mortality. However, the mechanisms driving cardiac injury and failure in COVID-19 are largely unknown. We performed plasma proteomics on 80 COVID-19 patients and controls, grouped according to disease severity and cardiac involvement. Findings were validated in 305 independent COVID-19 patients and investigated in an animal model. Here we show that senescence-associated secretory proteins, markers of biological aging, strongly associate with disease severity and cardiac involvement even in age-matched cohorts. FSTL3, an indicator of Activin/TGFβ signaling, was the most significantly upregulated protein associated with the heart failure biomarker, NTproBNP (β = 0.4;p
Identifiers
PMID34127963
PMCPMC8202429
OpenAlexW3169092764
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