Evidence map›Paper›PMID 34127929›Full record

ArticleFrontiers in genetics2021

MiR-3614-5p Is a Potential Novel Biomarker for Colorectal Cancer.

Lin Han, Yanjun Sun, Cansheng Lu, Chungeng Ma, Jian Shi, Dengqun Sun

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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  9. IFN-I inducibleFrontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lin HanGraduate School, Anhui University of Traditional Chinese Medicine, Hefei, China.
Yanjun SunDepartment of General Surgery, The Armed Police Corps Hospital of Anhui, Hefei, China.
Cansheng LuDepartment of Anus and Colon Surgery, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.
Chungeng MaDepartment of Anus and Colon Surgery, The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.
Jian ShiDepartment of Anus and Colon Surgery, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.
Dengqun SunDepartment of General Surgery, The Armed Police Corps Hospital of Anhui, Hefei, China.
Anhui University of Traditional Chinese Medicine · CNJiangSu Armed Police General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MiR-3614-5p has been found in a variety of cancers including colorectal cancer. However, the association of miR-3614-5p with colorectal cancer is still unclear. Based on the Cancer Genome Atlas (TCGA) database, the relationship between miR-3614-5p and colorectal cancer can be proved. Wilcoxon rank-sum test was used to compare the miR-3614-5p expression in colorectal cancer tissues and under normal conditions, respectively. The logistic regression method was further employed to analyze the relationship between miR-3614-5p and clinicopathological characteristics. Also, the correlation between miR-3614-5p and survival rate was evaluated by Kaplan-Meier and Cox regression analysis. Besides, gene set enrichment analysis (GSEA) was used to investigate the biological functions of miR-3614-5p. The decrease of miR-3614-5p expression of colorectal cancer was significantly correlated with N stage (OR) = 0.7 for N1&N2 vs. N0), M stage (OR = 0.5 for M1 vs. M0), pathologic stage (OR = 0.7 for Stage III & Stage IV vs. Stage I & Stage II), neoplasm type (OR = 0.5 for rectum adenocarcinoma vs. colon adenocarcinoma), and lymphatic invasion (OR = 0.6 for YES vs. NO) (all

Indexed as

colorectal cancerGSEAMiR-3614-5pprognosisTCGA

Identifiers

PMID34127929
PMCPMC8195682
OpenAlexW3172001152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.