ArticleNature materials2021
Kirigami-inspired stents for sustained local delivery of therapeutics.
Article in Nature materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 101 citations in OpenAlex.
- Oesophageal tissue screening system for assessing the retention and mucosal absorption of biologics.Nature biomedical engineering · 2026Article
- Origami Robotics in Biomedical Applications: A Paradigm Shift in Design and Innovation.Annals of biomedical engineering · 2026Review
- Polymerization Kinetics-Mediated Topological Entanglement Enables High-Contrast 3D Self-Morphing in Hydrogels.Angewandte Chemie (International ed. in English) · 2026Article
- Exploiting Device Deformability for Fluid and Particle Manipulation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Mechanochemical and machine-intelligent design of programmable materials: From molecular interactions to macroscale functionality.Materials today. Bio · 2026Review
- Rational assembly of 3D network materials and electronics through tensile buckling.Science advances · 2025Article
- Multi-Physically Programmable Tubular Origami Metamaterials: Exploitable Nexus of Geometry, Folding Mechanics and Stimuli-Responsive Physics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- FromMaterials today. Bio · 2025Review
- Silicon nano-kirigami with controlled plastic, elastic and hysteretic deformations.Nature communications · 2025Article
- Blueprints of Architected Materials: A Guide to Metamaterial Design for Tissue Engineering.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Wearable and Implantable Soft Robots.Chemical reviews · 2024Review
- Energy-efficient dynamic 3D metasurfaces via spatiotemporal jamming interleaved assemblies for tactile interfaces.Nature communications · 2024Article
- A mechanically robust and facile shape morphing using tensile-induced buckling.Science advances · 2024Article
- Optoelectronically navigated nano-kirigami microrotors.Science advances · 2024Article
- Bioinspired 3D flexible devices and functional systems.National science review · 2024Review
- Physics-aware differentiable design of magnetically actuated kirigami for shape morphing.Nature communications · 2023Article
- A reprogrammable mechanical metamaterial with origami functional-group transformation and ring reconfiguration.Nature communications · 2023Article
- Edible Origami Actuators Using Gelatin-Based Bioplastics.ACS applied polymer materials · 2023Article
- Transformative Materials for Interfacial Drug Delivery.Advanced healthcare materials · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, respiratory tract and vasculature all manifest with endoluminal disease. The anatomic distribution of localized drug delivery for these organs using existing therapeutic modalities is limited. Application of local depots in a circumferential and extended longitudinal fashion could transform our capacity to offer effective treatment across a range of conditions. Here we report the development and application of a kirigami-based stent platform to achieve this. The stents comprise a stretchable snake-skin-inspired kirigami shell integrated with a fluidically driven linear soft actuator. They have the capacity to deposit drug depots circumferentially and longitudinally in the tubular mucosa of the gastrointestinal tract across millimetre to multi-centimetre length scales, as well as in the vasculature and large airways. We characterize the mechanics of kirigami stents for injection, and their capacity to engage tissue in a controlled manner and deposit degradable microparticles loaded with therapeutics by evaluating these systems ex vivo and in vivo in swine. We anticipate such systems could be applied for a range of endoluminal diseases by simplifying dosing regimens while maximizing drug on-target effects through the sustained release of therapeutics and minimizing systemic side effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.