ArticleCommunications biology2021
Inter-individual body mass variations relate to fractionated functional brain hierarchies.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures.PLoS biology · 2026Article
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.Diabetes, obesity & metabolism · 2025Article
- Neural Correlates of Eating Habits and Nutritional Behaviors in the General Population: A Systematic Review of Observational Studies.Health science reports · 2025Review
- Transfer of motor learning is associated with patterns of activity in the default mode network.PLoS biology · 2025Article
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
- Novel Genes Associated With Working Memory Are Identified by Combining Connectome, Transcriptome, and Genome.Human brain mapping · 2025Article
- The macroscale routing mechanism of structural brain connectivity related to body mass index.Human brain mapping · 2024Article
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- Body mass index-dependent shifts along large-scale gradients in human cortical organization explain dietary regulatory success.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structural connectome alterations between individuals with autism and neurotypical controls using feature representation learning.Behavioral and brain functions : BBF · 2024Article
- Comparison of different group-level templates in gradient-based multimodal connectivity analysis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Identifying subgroups of eating behavior traits unrelated to obesity using functional connectivity and feature representation learning.Human brain mapping · 2024Article
- Diverging asymmetry of intrinsic functional organization in autism.Molecular psychiatry · 2023Article
- Is there a role for higher cognitive processes in the development of obesity in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Distinct patterns of cortical manifold expansion and contraction underlie human sensorimotor adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.Brain : a journal of neurology · 2022Article
- Disrupted stepwise functional brain organization in overweight individuals.Communications biology · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Variations in body mass index (BMI) have been suggested to relate to atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, we examined associations between functional connectivity and inter-individual BMI variations. We utilized non-linear connectome manifold learning techniques to represent macroscale functional organization along continuous hierarchical axes that dissociate low level and higher order brain systems. We observed an increased differentiation between unimodal and heteromodal association networks in individuals with higher BMI, indicative of a disrupted modular architecture and hierarchy of the brain. Transcriptomic decoding and gene enrichment analyses identified genes previously implicated in genome-wide associations to BMI and specific cortical, striatal, and cerebellar cell types. These findings illustrate functional connectome substrates of BMI variations in healthy young adults and point to potential molecular associations.
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