ArticleJournal of exposure science & environmental epidemiology2022
Expanding the environmental scope: an environment-wide association study for mental well-being.
Article in Journal of exposure science & environmental epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Adolescent wellbeing is associated with positive outcomes in early adulthood in a sibling comparison study.Nature communications · 2026Article
- Mapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis.Alpha psychiatry · 2025Article
- Living Near Contamination: The Impacts on Personal Well-Being.Applied research in quality of life · 2025Article
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- Building machine learning prediction models for well-being using predictors from the exposome and genome in a population cohort.Nature. Mental health · 2024Article
- Framework for Understanding and Addressing Racial and Ethnic Disparities in Children's Mental Health.Child and adolescent psychiatric clinics of North America · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIdentifying modifiable factors associated with well-being is of increased interest for public policy guidance. Developments in record linkage make it possible to identify what contributes to well-being from a myriad of factors. To this end, we link two large-scale data resources; the Geoscience and Health Cohort Consortium, a collection of geo-data, and the Netherlands Twin Register, which holds population-based well-being data.
objectiveWe perform an Environment-Wide Association Study (EnWAS), where we examine 139 neighbourhood-level environmental exposures in relation to well-being.
methodsFirst, we performed a generalized estimation equation regression (N = 11,975) to test for the effects of environmental exposures on well-being. Second, to account for multicollinearity amongst exposures, we performed principal component regression. Finally, using a genetically informative design, we examined whether environmental exposure is driven by genetic predisposition for well-being.
resultsWe identified 21 environmental factors that were associated with well-being in the domains: housing stock, income, core neighbourhood characteristics, livability, and socioeconomic status. Of these associations, socioeconomic status and safety are indicated as the most important factors to explain differences in well-being. No evidence of gene-environment correlation was found. SIGNIFICANCE: These observed associations, especially neighbourhood safety, could be informative for policy makers and provide public policy guidance to improve well-being. Our results show that linking databases is a fruitful exercise to identify determinants of mental health that would remain unknown by a more unilateral approach.
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