Evidence map›Paper›PMID 34127787›Full record

ArticleCommunications biology2021

Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics.

Isabel Wank, Pinelopi Pliota, Sylvia Badurek, Klaus Kraitsy, Joanna Kaczanowska, Johannes Griessner, Silke Kreitz, Andreas Hess, Wulf Haubensak

Abstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabel Wank *Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Pinelopi Pliota *Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Sylvia BadurekPreclinical Phenotyping Facility, Vienna Biocenter Core Facilities GmbH (VBCF), Vienna, Austria.ORCID 0000-0003-0808-2920
Klaus KraitsyPreclinical Phenotyping Facility, Vienna Biocenter Core Facilities GmbH (VBCF), Vienna, Austria.
Joanna KaczanowskaResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.ORCID 0000-0002-3166-9095
Johannes GriessnerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Silke KreitzInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Andreas HessInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Wulf HaubensakResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria. wulf.haubensak@imp.ac.at.ORCID 0000-0002-2034-9184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central amygdala (CE) emerges as a critical node for affective processing. However, how CE local circuitry interacts with brain wide affective states is yet uncharted. Using basic nociception as proxy, we find that gene expression suggests diverging roles of the two major CE neuronal populations, protein kinase C δ-expressing (PKCδ

Indexed as

AffectAmygdalaAnimalsMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, TransgenicNerve NetNociceptionOptogeneticsProtein Kinase C-deltaSomatostatinProtein Kinase C-deltaSomatostatin

Identifiers

PMID34127787
PMCPMC8203648

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.