Evidence map›Paper›PMID 34127705›Full record

ArticleScientific reports2021

Corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis exhibit sex-specific pain encoding in mice.

Waylin Yu, Christina M Caira, Natalia Del R Rivera Sanchez, Garrett A Moseley, Thomas L Kash

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  11. Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Waylin YuDepartment of Pharmacology, School of Medicine, University of North Carolina At Chapel Hill, CB 7178 Thurston Bowles Building, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Christina M CairaDepartment of Pharmacology, School of Medicine, University of North Carolina At Chapel Hill, CB 7178 Thurston Bowles Building, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Natalia Del R Rivera SanchezDepartment of Pharmacology, School of Medicine, University of North Carolina At Chapel Hill, CB 7178 Thurston Bowles Building, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Garrett A MoseleyDepartment of Pharmacology, School of Medicine, University of North Carolina At Chapel Hill, CB 7178 Thurston Bowles Building, 104 Manning Drive, Chapel Hill, NC, 27599, USA.
Thomas L KashDepartment of Pharmacology, School of Medicine, University of North Carolina At Chapel Hill, CB 7178 Thurston Bowles Building, 104 Manning Drive, Chapel Hill, NC, 27599, USA. thomas_kash@med.unc.edu.

Funding

PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIST32GM007040 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS, ROBERT A · 1985 to 2019
$6.0M
Determining the impact of BNST CRF systems on inflammatory pain-induced disruptions of behaviorR01NS122230 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KASH, THOMAS L. · 2021 to 2025
$2.0M
Dissecting the role of ethanol-induced plasticity in the PAG to BNST pathway in pain-related behaviorsR21AA027460 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KASH, THOMAS L. · 2019 to 2020
$399k
Midbrain and extended amygdala contributions to sex differences in pain and alcohol withdrawalF31AA027129 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YU, WAYLIN · 2018 to 2019
$73k
NIAAA NIH HHS F31AA027129NIAAA NIH HHS R21 AA027460NIGMS NIH HHS T32 GM007040NINDS NIH HHS R01 NS122230
6 · The paper itself

Abstract

The bed nucleus of the stria terminalis (BNST) plays an emerging role in pain regulation. Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling in the BNST can selectively mitigate the sensory and affective-motivational components of pain. However, mechanistic insight on the source of CRF that drives BNST responses to these harmful experiences remains unknown. In the present study, we used a series of genetic approaches to show that CRF in the BNST is engaged in the processing and modulation of pain. We conducted cell-type specific in vivo calcium imaging in CRF-Cre mice and found robust and synchronized recruitment of BNST

Indexed as

AnimalsCorticotropin-Releasing HormoneDisease Models, AnimalFemaleHot TemperatureHumansMaleMiceMice, TransgenicNeuronsNociceptionOptical ImagingPainSeptal NucleiSex FactorsCorticotropin-Releasing Hormone

Identifiers

PMID34127705
PMCPMC8203647

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.