Evidence map›Paper›PMID 34127675›Full record

ArticleNature communications2021

The insulo-opercular cortex encodes food-specific content under controlled and naturalistic conditions.

Yuhao Huang, Bina W Kakusa, Austin Feng, Sandra Gattas, Rajat S Shivacharan, Eric B Lee, Jonathon J Parker, Fiene M Kuijper, Daniel A N Barbosa, Corey J Keller and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuhao HuangDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Bina W KakusaDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0907-2505
Austin FengDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Sandra GattasDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Rajat S ShivacharanDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Eric B LeeDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3659-1020
Jonathon J ParkerDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Fiene M KuijperDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Daniel A N BarbosaDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7272-1446
Corey J KellerDepartments of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Cara BohonDepartments of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Abanoub MikhailDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Casey H HalpernDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. chalpern@stanford.edu.

Funding

Transitioning Early Career Neurosurgeons to Scientific IndependenceK12NS080223 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2012 to 2022
$9.2M
Neocortical-Hippocampal Circuits Underlying Pattern Separation in HumansF30AG069406 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI GATTAS, SANDRA · 2020 to 2023
$136k
NIA NIH HHS F30 AG069406NINDS NIH HHS K12 NS080223
6 · The paper itself

Abstract

The insulo-opercular network functions critically not only in encoding taste, but also in guiding behavior based on anticipated food availability. However, there remains no direct measurement of insulo-opercular activity when humans anticipate taste. Here, we collect direct, intracranial recordings during a food task that elicits anticipatory and consummatory taste responses, and during ad libitum consumption of meals. While cue-specific high-frequency broadband (70-170 Hz) activity predominant in the left posterior insula is selective for taste-neutral cues, sparse cue-specific regions in the anterior insula are selective for palatable cues. Latency analysis reveals this insular activity is preceded by non-discriminatory activity in the frontal operculum. During ad libitum meal consumption, time-locked high-frequency broadband activity at the time of food intake discriminates food types and is associated with cue-specific activity during the task. These findings reveal spatiotemporally-specific activity in the human insulo-opercular cortex that underlies anticipatory evaluation of food across both controlled and naturalistic settings.

Indexed as

FoodAdultCerebral CortexCuesElectroencephalographyElectrophysiological PhenomenaFemaleFrontal LobeHumansMaleMiddle AgedTasteTaste PerceptionYoung Adult

Identifiers

PMID34127675
PMCPMC8203663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.