ArticleCancer research2021
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
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Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
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Who cites it
46 citing papers in PubMed, 62 citations in OpenAlex.
- Cancer-derived lactic acid as a potential upstream contributor to tumor hypoxia.Communications biology · 2026Review
- Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations.Endocrine-related cancer · 2026Review
- Polyunsaturated fatty acid sequestration protects against mitochondrial dysfunction-induced ferroptosis.EMBO reports · 2026Article
- Iron-Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol-Related Lipid Metabolic Diseases.Journal of biochemical and molecular toxicology · 2026Review
- TRIM47 drives metabolic reprogramming and tumor progression in Nasopharyngeal Carcinoma via K48-linked ubiquitination and degradation of SDHB.Cellular and molecular life sciences : CMLS · 2026Article
- 630 nm LED phototherapy enhances ovarian function and fertility potential in advanced reproductive age females.Bioengineering & translational medicine · 2026Article
- Succinate dehydrogenase-deficient cancer cells have increased susceptibility to Ym155-induced DNA damage.Endocrine-related cancer · 2026Article
- Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway.Human cell · 2026Article
- Mitochondria-related genes or proteins affect the progression of hepatocellular carcinoma: roles, mechanisms and potential treatments.American journal of cancer research · 2026Review
- Bladder Paraganglioma With Rapid Metastasis: A Case Report and Review of the Literature.Cureus · 2026Article
- Identification of Hub genes in melasma using integrated transcriptomic analysis.Bioinformation · 2026Article
- NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis.Nature communications · 2025Article
- Mitochondrial electron transport chain gene-based prognostic model identifies SDHB as a key regulator of low-grade glioma progression and therapeutic target.Cancer cell international · 2025Article
- Cardiometabolic disease and cardio-oncology: Insights from iPSC models and tissue engineering.Cell reports. Medicine · 2025Review
- Transcriptome analysis of heterografting on key medicinal compounds accumulation in Ziziphi Spinosae Semen.BMC plant biology · 2025Article
- Rapid generation of a sdhb loss-of-function zebrafish model for secreting pheochromocytomas and paragangliomas.NPJ genomic medicine · 2025Article
- Metabolic Effects of Succinate Dehydrogenase Loss in Cancer.Journal of cellular physiology · 2025Review
- Postnatal epigenetic differences in calves following transient fetal infection with bovine viral diarrhea virus.BMC genomics · 2025Article
- Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy.Cancer metastasis reviews · 2025Review
- SDH defective cancers: molecular mechanisms and treatment strategies.Cell biology and toxicology · 2025Review
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 2 countries.
Judith GoncalvesPARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.ORCID 0000-0002-6367-8527
Sophie Moog *PARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.ORCID 0000-0001-9920-0480
Aurélie Morin *PARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.ORCID 0000-0003-2048-6805
Géraldine GentricStress and Cancer Laboratory, Institut Curie, Equipe Labellisée par la Ligue Nationale contre le Cancer, Inserm U830, PSL Research University, Paris France.ORCID 0000-0002-7558-8705
Sebastian MüllerChemical Biology of Cancer Team, Equipe Labellisée par la Ligue Contre le Cancer, PSL Research University, CNRS UMR3666 -INSERM U1143, Institut Curie, Paris, France.ORCID 0000-0002-3423-5364
Alexander P MorrellCentre for Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0003-3763-5846
Katarina KluckovaInstitute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, \United Kingdom.
Theodora J StewartLondon Metallomics Facility, King's College London and Imperial College London, London, United Kingdom.ORCID 0000-0002-5651-8664
Cynthia L AndoniadouCentre for Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London.ORCID 0000-0003-4311-5855
Charlotte Lussey-LepoutrePARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.
Paule BénitUniversité de Paris, INSERM, UMR 1141, Hôpital Robert Debré, Paris, France.
Alpesh ThakkerInstitute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, \United Kingdom.
Lisa VettoreInstitute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, \United Kingdom.
Jennie RobertsInstitute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, \United Kingdom.
Raphaël RodriguezChemical Biology of Cancer Team, Equipe Labellisée par la Ligue Contre le Cancer, PSL Research University, CNRS UMR3666 -INSERM U1143, Institut Curie, Paris, France.ORCID 0000-0001-7668-446X
Fatima Mechta-GrigoriouStress and Cancer Laboratory, Institut Curie, Equipe Labellisée par la Ligue Nationale contre le Cancer, Inserm U830, PSL Research University, Paris France.ORCID 0000-0002-3751-6989
Anne-Paule Gimenez-RoqueploPARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.ORCID 0000-0002-4816-670X
Eric LetouzéCentre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Paris France.ORCID 0000-0002-6369-2839
Daniel A TennantInstitute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, \United Kingdom.ORCID 0000-0003-0499-2732
Judith FavierPARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France. judith.favier@inserm.fr.
Inserm · FRThe Edgbaston Hospital · GBCentre National de la Recherche Scientifique · FRKing's College London · GB
Funding
Cancer Research UK 24757European Research Council 647973Wellcome Trust 202902Wellcome Trust 202902/Z/16/Z
Abstract
Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit are associated with increased risk of metastasis. Here we generated an
Indexed as
HomeostasisMutationOxidative StressAnimalsAntioxidantsAscorbic AcidDioxygenasesFemaleIronMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaPhenotypeReactive Oxygen SpeciesAntioxidantsAscorbic AcidDioxygenasesIronReactive Oxygen SpeciesSuccinate Dehydrogenase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.