ArticleBMJ open2021
Effect of multimorbidity patterns on the decline in health-related quality of life: a nationwide prospective cohort study in Japan.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Patterns of multimorbidity, their outcomes and analytical methods for their determination: a systematic review.BMC public health · 2026Pooled it
- Reporting and representation of underserved groups in intervention studies for patients with multiple long-term conditions: a systematic review.Journal of the Royal Society of Medicine · 2024Pooled it
- Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis.PLoS medicine · 2023Pooled it
- Multimorbidity Among Patients Receiving Home Care in Japan: Prevalence, Levels, and Association With Emergency Home Visits.Journal of general and family medicine · 2026Article
- Time toxicity in chronic disease comorbidity care: A concept analysis using Walker and Avant's approach.International journal of nursing sciences · 2026Article
- Functional dependency level and later-life incident multimorbidity in older people: longitudinal evidence from 19 countries in China and Europe.BMC public health · 2025Article
- The quality of life and related factors in older adults with possible sarcopenia and sarcopenia in rural areas of Xinjiang, China: a cross sectional study.BMC geriatrics · 2025Article
- Trends in prescriptions and factors associated with discontinuation of potentially inappropriate medications in elderly patients with advanced cancer at the end of life: A retrospective cohort study.Palliative care and social practice · 2025Article
- Prevalence, patterns of multimorbidity, and its correlations with health-related quality of life in rural southwest China: a cross-sectional study.Frontiers in medicine · 2025Article
- The characteristics of general practitioners and geriatricians who take overall responsibility for the care of older patients with multimorbidity.Journal of general and family medicine · 2024Article
- Article
- Multimorbidity patterns and the relation to self-rated health among older Japanese people: a nationwide cross-sectional study.BMJ open · 2022Article
- Physical function and health-related quality of life of community-dwelling older adults with locomotive syndrome and pre-frailty.Journal of physical therapy science · 2022Article
- Relationship between Multimorbidity and Quality of Life in a Primary Care Setting: The Mediating Role of Dyspnea.Journal of clinical medicine · 2022Article
- Multimorbidity patterns by health-related quality of life status in older adults: an association rules and network analysis utilizing the Korea National Health and Nutrition Examination Survey.Epidemiology and health · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLongitudinal studies, which consider multimorbidity patterns, are useful for better clarifying the effect of multimorbidity on health-related quality of life (HRQoL) and for identifying the target population with poorer clinical outcomes among patients with multimorbidity. This study aimed to examine the effects of different multimorbidity patterns on the decline in HRQoL.
designNationwide prospective cohort study.
settingJapanese adult residents.
participantsResidents aged ≥50 years selected by the quota sampling method. PRIMARY OUTCOME MEASURE: Clinically relevant decline in HRQoL was defined as a 0.50 SD (5-point) decrease in the 36-Item Short Form Health Survey (SF-36) component summary scores for 1 year.
resultsIn total, 1211 participants completed the follow-up survey. Among the multimorbidity patterns identified using confirmatory factor analysis, multivariable logistic regression analyses revealed that high cardiovascular/renal/metabolic and malignant/digestive/urologic pattern scores were significantly associated with the clinically relevant decline in SF-36 physical component summary score (adjusted OR (aOR)=1.25, 95% CI: 1.08 to 1.44 and aOR=1.28, 95% CI: 1.04 to 1.58, respectively). High cardiovascular/renal/metabolic pattern score was also significantly associated with the clinically relevant decline in SF-36 role/social component summary score (aOR=1.23, 95% CI: 1.06 to 1.42).
conclusionsOur study revealed that multimorbidity patterns have different effects on the clinically relevant decline in HRQoL for 1 year. These findings can be useful in identifying populations at high risk and with poor clinical outcomes among patients with chronic diseases and multimorbidity for efficient resource allocation.
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