Evidence map›Paper›PMID 34127450›Full record

ReviewCold Spring Harbor perspectives in biology2021

Imaging Organization of RNA Processing within the Nucleus.

Jeetayu Biswas, Weihan Li, Robert H Singer, Robert A Coleman

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Aberrant pre-mRNA processing in cancer.The Journal of experimental medicine · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Research progress of live-cell RNA imaging techniques.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeetayu BiswasDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.ORCID 0000-0002-1163-539X
Weihan LiDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Robert H SingerDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.ORCID 0000-0002-6725-0093
Robert A ColemanDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Albert Einstein College of Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Mechanism of MRNA Localization and Localized Translation in NeuronsR01NS083085 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sulagna Das, Robert H Singer · 2013 to 2026
$9.0M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Dissecting the Dynamic Interplay Between, p53, Chromatin and Transcriptional Bursting in Single CellsR01GM126045 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI COLEMAN, ROBERT · 2018 to 2025
$2.9M
Following mRNA from birth to death at single-molecule resolutionR35GM136296 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2020 to 2024
$2.3M
Tools For Imaging the Functional Genome in Living Cells and TissuesU01DA047729 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DARZACQ, XAVIER, SINGER, ROBERT H · 2018 to 2019
$1.7M
The sequence recognition, structure and function of the IMP family of mRNA binding proteinsF30CA214009 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BISWAS, JEETAYU · 2017 to 2020
$199k
NCI NIH HHS F30 CA214009NICHD NIH HHS P50 HD105352NIDA NIH HHS U01 DA047729NIGMS NIH HHS R01 GM126045NIGMS NIH HHS R35 GM136296NIGMS NIH HHS T32 GM007288NINDS NIH HHS R01 NS083085
6 · The paper itself

Abstract

Within the nucleus, messenger RNA is generated and processed in a highly organized and regulated manner. Messenger RNA processing begins during transcription initiation and continues until the RNA is translated and degraded. Processes such as 5' capping, alternative splicing, and 3' end processing have been studied extensively with biochemical methods and more recently with single-molecule imaging approaches. In this review, we highlight how imaging has helped understand the highly dynamic process of RNA processing. We conclude with open questions and new technological developments that may further our understanding of RNA processing.

Indexed as

Cell NucleusRNAAlternative SplicingRNA, MessengerSingle Molecule ImagingTranscription, GeneticRNARNA, Messenger

Identifiers

PMID34127450
PMCPMC8635003
OpenAlexW3167400297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.