Evidence map›Paper›PMID 34127448›Full record

ReviewCold Spring Harbor perspectives in biology2022

The Nuclear Pore Complex as a Transcription Regulator.

Michael Chas Sumner, Jason Brickner

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. RiboScreenBiomedicines · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael Chas SumnerDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.ORCID 0000-0001-7596-9543
Jason BricknerDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.ORCID 0000-0001-8019-3743
Northwestern University · US

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
The molecular mechanisms and functional significance of gene positioningR35GM136419 · NIGMS · NORTHWESTERN UNIVERSITY · PI BRICKNER, JASON HAYS · 2020 to 2024
$2.9M
Defining the molecular and cellular mechanism of epigenetic transcriptional memoryR01GM118712 · NIGMS · NORTHWESTERN UNIVERSITY · PI BRICKNER, JASON HAYS · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM118712NIGMS NIH HHS R35 GM136419NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal loci physically interact with nuclear pore proteins (Nups), and interactions with Nups can promote transcriptional repression, transcriptional activation, and transcriptional poising. Interaction with the NPC also affects the spatial arrangement of genes, interchromosomal clustering, and folding of topologically associated domains. Thus, the NPC is a spatial organizer of the genome and regulator of genome function.

Indexed as

Nuclear PoreNuclear Pore Complex ProteinsActive Transport, Cell NucleusGenomeProtein TransportNuclear Pore Complex Proteins

Identifiers

PMID34127448
PMCPMC8725628
OpenAlexW3169157739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.