Evidence map›Paper›PMID 34127057›Full record

ReviewEuropean journal of medical research2021

The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?

Henning Madry, Susanne Grässel, Ulrich Nöth, Borna Relja, Anke Bernstein, Denitsa Docheva, Max Daniel Kauther, Jan Christoph Katthagen, Rainer Bader, Martijn van Griensven and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in European journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Effects of anesthesia with sevoflurane on outcome parameters in murine experimental studies.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  4. Article
  5. Article
  6. Research in orthopaedic trauma surgery: approaches of basic scientists and clinicians and the relevance of interprofessional research teams.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 2 countries.

Henning MadryInstitute of Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Homburg, Germany.
Susanne GrässelExperimental Orthopedics, Department of Orthopedic Surgery, University of Regensburg, Regensburg, Germany.
Ulrich NöthDepartment of Orthopaedics and Trauma Surgery, Evangelisches Waldkrankenhaus Berlin Spandau, Berlin, Germany.
Borna ReljaExperimental Radiology, University Clinic for Radiology and Nuclear Medicine, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Anke BernsteinG.E.R.N. Research Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center - Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Breisgau, Germany.
Denitsa DochevaExperimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, Regensburg, Germany.
Max Daniel KautherDepartment of Trauma-, Hand- and Reconstructive Surgery, University Hospital Essen, Essen, Germany.
Jan Christoph KatthagenDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany.
Rainer BaderDepartment of Orthopaedics, Research Lab for Biomechanics and Implant Technology, Rostock University Medical Center, Rostock, Germany.
Martijn van GriensvenDepartment of Cell Biology-Inspired Tissue Engineering, MERLN-Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.
Dieter C WirtzDepartment of Orthopaedics and Trauma Surgery, University Hopsital Bonn, Bonn, Germany.
Michael J RaschkeDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, Muenster, Germany.
Markus Huber-LangInstitute for Clinical and Experimental Trauma-Immunology (ITI), University Hospital Ulm, Helmholzstr. 8/1, Ulm, Germany. markus.huber-lang@uniklinik-ulm.de.ORCID http://orcid.org/0000-0003-2359-6516
University Hospital Münster · DEEssen University Hospital · DEMaastricht University · NLOtto-von-Guericke-Universität Magdeburg · DESaarland University · DEUniversity Hospital Bonn · DEUniversity Hospital Regensburg · DEUniversity Hospital Ulm · DEUniversity of Freiburg · DEUniversity of Regensburg · DEUniversity of Rostock · DEWaldkrankenhaus Protestant Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthopaedic and trauma research is a gateway to better health and mobility, reflecting the ever-increasing and complex burden of musculoskeletal diseases and injuries in Germany, Europe and worldwide. Basic science in orthopaedics and traumatology addresses the complete organism down to the molecule among an entire life of musculoskeletal mobility. Reflecting the complex and intertwined underlying mechanisms, cooperative research in this field has discovered important mechanisms on the molecular, cellular and organ levels, which subsequently led to innovative diagnostic and therapeutic strategies that reduced individual suffering as well as the burden on the society. However, research efforts are considerably threatened by economical pressures on clinicians and scientists, growing obstacles for urgently needed translational animal research, and insufficient funding. Although sophisticated science is feasible and realized in ever more individual research groups, a main goal of the multidisciplinary members of the Basic Science Section of the German Society for Orthopaedics and Trauma Surgery is to generate overarching structures and networks to answer to the growing clinical needs. The future of basic science in orthopaedics and traumatology can only be managed by an even more intensified exchange between basic scientists and clinicians while fuelling enthusiasm of talented junior scientists and clinicians. Prioritized future projects will master a broad range of opportunities from artificial intelligence, gene- and nano-technologies to large-scale, multi-centre clinical studies. Like Prometheus in the ancient Greek myth, transferring the elucidating knowledge from basic science to the real (clinical) world will reduce the individual suffering from orthopaedic diseases and trauma as well as their socio-economic impact.

Indexed as

Artificial IntelligenceBiomedical ResearchHumansOrthopedicsTraumatologyBasic scienceFutureNeedsOrthopaedicsResearch agendaTraumatology

Identifiers

PMID34127057
PMCPMC8200553
OpenAlexW3172755625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.