Evidence map›Paper›PMID 34127055›Full record

ArticleSystematic reviews2021

Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol.

Mathieu Laflamme, Hourmazd Haghbayan, Manoj M Lalu, Ryan Zarychanski, François Lauzier, Amélie Boutin, Malcolm R Macleod, Dean A Fergusson, Lynne Moore, Olivier Costerousse and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mathieu LaflammeCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval, Québec, QC, Canada.
Hourmazd HaghbayanCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval, Québec, QC, Canada.
Manoj M LaluClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ryan ZarychanskiDepartment of Internal Medicine, Sections of Critical Care Medicine, of Hematology and of Medical Oncology, Rady Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
François LauzierCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval, Québec, QC, Canada.
Amélie BoutinDepartment of Pediatrics, Université Laval, Québec, QC, Canada.
Malcolm R MacleodCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Dean A FergussonClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Lynne MooreCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval, Québec, QC, Canada.
Olivier CosterousseCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval, Québec, QC, Canada.
Jacques LacroixDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
Cheryl WellingtonDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Jamie HutchisonDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Alexis F TurgeonCHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval, Québec, QC, Canada. Alexis.Turgeon@fmed.ulaval.ca.ORCID 0000-0001-5675-8791
Canadian Traumatic Brain Injury Research Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models.

methodsWe will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE, and Web of Science databases for eligible studies from inception onwards. Two independent reviewers will perform study selection and data extraction. We will report our results in a descriptive synthesis focusing on characteristics of included studies, reported outcomes, risk of bias, and construct validity. Our primary outcome is the neurological function (neurobehavioral performance) and our secondary outcomes include mortality, infarct size, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and brain tissue oxygen tension. If appropriate, we will also perform a quantitative synthesis and pool results using random-effect models. Heterogeneity will be expressed with I DISCUSSION: Our study is aligned with the efforts to better understand the level of evidence on the impact of red blood cell transfusion strategies from preclinical studies in animal models of acute brain injury and the potential translation of information from the preclinical to the clinical research field. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018086662 .

Indexed as

AnemiaBrain InjuriesAnimalsBlood TransfusionErythrocyte TransfusionHumansModels, AnimalSystematic Reviews as TopicAnimal modelsBlood productsCerebral hemorrhageRed blood cell transfusionStrokeTraumatic brain injury

Identifiers

PMID34127055
PMCPMC8201673

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.