Evidence map›Paper›PMID 34127040›Full record

ArticleTrials2021

Short-term effects of synchronized vs. non-synchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial.

Francesco Cresi, Federica Chiale, Elena Maggiora, Silvia Maria Borgione, Mattia Ferroglio, Federica Runfola, Giulia Maiocco, Chiara Peila, Enrico Bertino, Alessandra Coscia

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03289936 (Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03289936 naunknown statusnot on this map

Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants: Study Protocol for an Unmasked Randomized Crossover Trial.

TypeinterventionalSponsorUniversity of Turin, ItalyRan2020 to 2024Enrolled30ConditionsNewborn Respiratory Distress, Preterm InfantArmsNIPPV, SNIPPV
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. The effect of changing respiratory rate settings on COJournal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Francesco CresiNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Federica ChialeNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy. federica.chiale@gmail.com.ORCID http://orcid.org/0000-0003-2857-7453
Elena MaggioraNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Silvia Maria BorgioneNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Mattia FerroglioNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Federica RunfolaNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Giulia MaioccoNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Chiara PeilaNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Enrico BertinoNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
Alessandra CosciaNeonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.
University of Turin · ITDepartment of Public Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-invasive ventilation (NIV) has been recommended as the best respiratory support for preterm infants with respiratory distress syndrome (RDS). However, the best NIV technique to be used as first intention in RDS management has not yet been established. Nasal intermittent positive pressure ventilation (NIPPV) may be synchronized (SNIPPV) or non-synchronized to the infant's breathing efforts. The aim of the study is to evaluate the short-term effects of SNIPPV vs. NIPPV on the cardiorespiratory events, trying to identify the best ventilation modality for preterm infants at their first approach to NIV ventilation support.

methodsAn unmasked randomized crossover study with three treatment phases was designed. All newborn infants < 32 weeks of gestational age with RDS needing NIV ventilation as first intention or after extubation will be consecutively enrolled in the study and randomized to the NIPPV or SNIPPV arm. After stabilization, enrolled patients will be alternatively ventilated with two different techniques for two time frames of 4 h each. NIPPV and SNIPPV will be administered with the same ventilator and the same interface, maintaining continuous assisted ventilation without patient discomfort. During the whole duration of the study, the patient's cardiorespiratory data and data from the ventilator will be simultaneously recorded using a polygraph connected to a computer. The primary outcome is the frequency of episodes of oxygen desaturation. Secondary outcomes are the number of the cardiorespiratory events, FiO DISCUSSION: It is known that NIPPV produces a percentage of ineffective acts due to asynchronies between the ventilator and the infant's breaths. On the other hand, an ineffective synchronization could increase work of breathing. Our hypothesis is that an efficient synchronization could reduce the respiratory work and increase the volume per minute exchanged without interfering with the natural respiratory rhythm of the patient with RDS. The results of this study will allow us to evaluate the effectiveness of the synchronization, demonstrating whether SNIPPV is the most effective non-invasive ventilation mode in preterm infants with RDS at their first approach to NIV ventilation.

trial registrationClinicalTrials.gov NCT03289936 . Registered on September 21, 2017.

Indexed as

Intermittent Positive-Pressure VentilationRespiratory Distress Syndrome, NewbornContinuous Positive Airway PressureCross-Over StudiesHumansInfantInfant, NewbornInfant, PrematurePositive-Pressure RespirationRandomized Controlled Trials as TopicCardiorespiratory eventsNIPPVNon-invasive ventilationPreterm infantsRDSSNIPPVSynchronization

Identifiers

PMID34127040
PMCPMC8200781
OpenAlexW3134728651

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.