Evidence map›Paper›PMID 34127013›Full record

ArticleRadiation oncology (London, England)2021

A novel external beam radiotherapy method for cervical cancer patients using virtual straight or bending boost areas; an in-silico feasibility study.

Luca Cozzi, Sushil Beriwal, Esa Kuusela, Supriya Chopra, Hester Burger, Nanette Joubert, Antonella Fogliata, Jai Prakash Agarwal, Pat Kupelian

Open access · goldAbstract read
In one paragraph

Article in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Luca CozziRadiotherapy and Radiosurgery Department, Humanitas Research Hospital and Cancer Center, Via Manzoni 56, 20089, Milan-Rozzano, Italy. luca.cozzi@humanitas.it.ORCID http://orcid.org/0000-0001-7862-898X
Sushil BeriwalDepartment of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Esa KuuselaVarian Medical Systems Finland, Helsinki, Finland.
Supriya ChopraDepartment of Radiation Oncology, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Homi Bhaba National Institute, Mumbai, India.
Hester BurgerDivision of Medical Physics, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Nanette JoubertDivision of Medical Physics, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Antonella FogliataRadiotherapy and Radiosurgery Department, Humanitas Research Hospital and Cancer Center, Via Manzoni 56, 20089, Milan-Rozzano, Italy.
Jai Prakash AgarwalDepartment of Radiation Oncology, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Homi Bhaba National Institute, Mumbai, India.
Pat KupelianVarian Medical Systems, Palo Alto, USA.
Homi Bhabha National Institute · INUniversity of Cape Town · ZAIRCCS Humanitas Research Hospital · ITUniversity of California, Los Angeles · USUPMC Hillman Cancer Center · USVarian Medical Systems (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the potential role of a novel spatially fractionated radiation therapy (SFRT) method where heterogeneous dose patterns are created in target areas with virtual rods, straight or curving, of variable position, diameter, separation and alignment personalised to a patient's anatomy. The images chosen for this study were CT scans acquired for the external beam part of radiotherapy.

methodsTen patients with locally advanced cervical cancer were retrospectively investigated with SFRT. The dose prescription was 30 Gy in 5 fractions to 90% target volume coverage. Peak-and-valley (SFRT_1) and peak-only (SFRT_2) strategies were applied to generate the heterogeneous dose distributions. The planning objectives for the target (CTV) were D

resultsThe D

Indexed as

Computer SimulationBrachytherapyFeasibility StudiesFemaleHumansOrgans at RiskPrognosisRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective StudiesUterine Cervical NeoplasmsCervix uteri cancerRapidArcSpatially fractionated radiation therapyVirtual brachytherapyVMAT

Identifiers

PMID34127013
PMCPMC8201836
OpenAlexW3166843918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.