Evidence map›Paper›PMID 34126877›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.

Alexia Perryman, Adam M Speen, Hye-Young H Kim, Jessica R Hoffman, Phillip W Clapp, William Rivera Martin, John N Snouwaert, Beverly H Koller, Ned A Porter, Ilona Jaspers

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. The Flying Monkeys of Ozone: Oxysterols Inactivate NLRP2 in Airway Epithelial Cells.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alexia PerrymanCenter for Environmental Medicine, Asthma, and Lung Biology.
Adam M SpeenCenter for Environmental Medicine, Asthma, and Lung Biology.
Hye-Young H KimDepartment of Chemistry and Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee.
Jessica R HoffmanCenter for Environmental Medicine, Asthma, and Lung Biology.
Phillip W ClappCenter for Environmental Medicine, Asthma, and Lung Biology.
William Rivera MartinCenter for Environmental Medicine, Asthma, and Lung Biology.
John N SnouwaertDepartment of Genetics, and.
Beverly H KollerDepartment of Genetics, and.
Ned A PorterDepartment of Chemistry and Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee.
Ilona JaspersCenter for Environmental Medicine, Asthma, and Lung Biology.
Center for Environmental Health · USVanderbilt University · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Ozone, oxysterols, and lung inflammationR01ES028269 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, PORTER, NED ALLEN · 2018 to 2023
$2.8M
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES028269NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

Ozone (O

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SubstitutionApoptosis Regulatory ProteinsBronchiEpithelial CellsGene Expression RegulationHumansImmunoblottingInflammasomesInflammationInterleukin-8OxysterolsOzoneAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCXCL8 protein, humanInflammasomesInterleukin-8NLRP2 protein, humanOxysterolsOzonecholesterollipidlungNod‐like receptorsecosterol A

Identifiers

PMID34126877
PMCPMC8641854
OpenAlexW3170168811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.