Evidence map›Paper›PMID 34126773›Full record

ArticlemBio2021

An Egg-Derived Sulfated

Jenna J Guthmiller, Henry A Utset, Carole Henry, Lei Li, Nai-Ying Zheng, Weina Sun, Marcos Costa Vieira, Seth Zost, Min Huang, Scott E Hensley and 3 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Preliminary Findings From the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jenna J GuthmillerDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
Henry A UtsetDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
Carole HenryDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
Lei LiDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
Nai-Ying ZhengDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
Weina SunDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Marcos Costa VieiraDepartment of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA.
Seth ZostDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Min HuangDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
Scott E HensleyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sarah CobeyDepartment of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA.
Peter PaleseDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Patrick C WilsonDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA.
University of Chicago · USIcahn School of Medicine at Mount Sinai · USUniversity of Pennsylvania · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WILSON, PATRICK CHRISTOPHER · 2012 to 2022
$17.6M
Understanding Human B Cell Responses to Influenza to Improve the Influenza U19AI109946 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAVETCH, JEFFREY VICTOR · 2014 to 2018
$9.6M
Evaluation of the FcgR mechanisms in the antibody-dependent enhancement of SARS-CoV-2 infectionR01AI145870 · NIAID · ROCKEFELLER UNIVERSITY · PI Peter Palese, JEFFREY Victor RAVETCH · 2019 to 2026
$8.4M
University of Chicago Autoimmunity Center of ExcellenceU19AI082724 · NIAID · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 2009 to 2023
$7.2M
Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
NIAID NIH HHS 75N93019C00051NIAID NIH HHS HHSN272201400005CNIAID NIH HHS HHSN272201400008CNIAID NIH HHS P01 AI097092NIAID NIH HHS R01 AI145870NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI082724NIAID NIH HHS U19 AI109946NIGMS NIH HHS R24 GM137763
6 · The paper itself

Abstract

Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated

Indexed as

Amino SugarsAnimalsAntibodies, MonoclonalAntibodies, ViralAntigens, ViralCell LineChickensEggsEpitopesHEK293 CellsHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A virusInfluenza VaccinesPolysaccharidesAmino SugarsAntibodies, MonoclonalAntibodies, ViralAntigens, ViralEpitopesHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesN-acetyllactosaminePolysaccharidesantibody repertoireanti-glycan antibodiesinfluenza vaccinesLacNAcvaccine platform

Identifiers

PMID34126773
PMCPMC8263001
OpenAlexW3167322838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.