Evidence map›Paper›PMID 34126767›Full record

ArticlemBio2021

Genome-Wide Essentiality Analysis of

Dalin Rifat, Liang Chen, Barry N Kreiswirth, Eric L Nuermberger

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CRISPRi-mediatedAntimicrobial agents and chemotherapy · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Journal of bacteriology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. CRISPRi-mediated validation of candidatebioRxiv : the preprint server for biology · 2025
    Article
  14. Review
  15. Functional (re)annotation ofCurrent research in structural biology · 2025
    Article
  16. Article
  17. Article
  18. The role of colony morphotype in shaping gene essentiality inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dalin RifatThe Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Liang ChenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Eric L NuermbergerThe Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Hackensack Meridian Health · USJohns Hopkins University · US

Funding

Dissecting the molecular targets to overcome beta-lactam resistance in M. abscessus complexR01AI141805 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI BARRY Neal KREISWIRTH · 2019 to 2026
$5.1M
Exploiting a robust drug discovery portfolio to develop effective regimens to treat Mycobacterium abscessus lung infectionR21AI137814 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L · 2018 to 2019
$450k
NIAID NIH HHS R01 AI141805NIAID NIH HHS R21 AI137814
6 · The paper itself

Abstract

Mycobacterium abscessus is an emerging opportunistic human pathogen that naturally resists most major classes of antibiotics, making infections difficult to treat. Thus far, little is known about

Indexed as

DNA Transposable ElementsGenes, EssentialGenome, BacterialGenomicsHigh-Throughput Nucleotide SequencingHumansMutagenesis, InsertionalMycobacterium abscessusMycobacterium tuberculosisDNA Transposable Elementsdeep sequencingessential geneessentialitygene disruptiongeneticsgenomicsHimar1 mutagenesismycobacteriumMycobacterium abscessustransposontransposon sequencing (Tn-Seq)

Identifiers

PMID34126767
PMCPMC8262987
OpenAlexW3172842382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.