Evidence map›Paper›PMID 34126763›Full record

ArticlemBio2021

Mechanisms of Transforming DNA Uptake to the Periplasm of Bacillus subtilis.

Jeanette Hahn, Micaela DeSantis, David Dubnau

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Watching DNA uptake:Journal of bacteriology · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. The RecA-directed recombination pathway of natural transformation initiates at chromosomal replication forks in the pneumococcus.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeanette HahnPublic Health Research Institute, Rutgers University, Newark, New Jersey, USA.
Micaela DeSantisPublic Health Research Institute, Rutgers University, Newark, New Jersey, USA.
David DubnauPublic Health Research Institute, Rutgers University, Newark, New Jersey, USA.
Rutgers, The State University of New Jersey · US

Funding

Understanding the mechanism of genetic transformationR01GM057720 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DAVID A DUBNAU, Matthew B Neiditch · 1998 to 2026
$15.4M
NIGMS NIH HHS R01 GM057720
6 · The paper itself

Abstract

We demonstrate here that the acquisition of DNase resistance by transforming DNA, often assumed to indicate transport to the cytoplasm, reflects uptake to the periplasm, requiring a reevaluation of conclusions about the roles of several proteins in transformation. The new evidence suggests that the transformation pilus is needed for DNA binding to the cell surface near the cell poles and for the initiation of uptake. The cellular distribution of the membrane-anchored ComEA of Bacillus subtilis does not dramatically change during DNA uptake as does the unanchored ComEA of

Indexed as

Transformation, BacterialBacillus subtilisBiological TransportCell MembraneDNA, BacterialMembrane ProteinsPeriplasmDNA, BacterialMembrane ProteinsBacillus subtilisComEAComECDNA uptakeperiplasmtransformation

Identifiers

PMID34126763
PMCPMC8262900
OpenAlexW3171219250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.