Evidence map›Paper›PMID 34126706›Full record

ArticleEpidemiology and health2021

Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea.

Naharin Sultana Anni, Sun Jae Jung, Jee-Seon Shim, Yong Woo Jeon, Ga Bin Lee, Hyeon Chang Kim

Open access · diamondAbstract read
In one paragraph

Article in Epidemiology and health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The Metabolomic Signature of Stressful Life Events.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Naharin Sultana AnniDepartment of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Sun Jae JungDepartment of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Jee-Seon ShimDepartment of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Yong Woo JeonDepartment of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Ga Bin LeeDepartment of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Hyeon Chang KimDepartment of Public Health, Graduate School, Yonsei University, Seoul, Korea.
Yonsei University · KR

Funding

Korea Health Industry Development InstituteMinistry of Health and Welfare HI13C0715Ministry of Science and ICTNational Research Foundation of Korea 2019R1A4A1028155
6 · The paper itself

Abstract

objectivesElevated serum triglyceride levels are a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life events (SLEs) on serum triglyceride levels in the healthy population. Therefore, we evaluated the independent association between SLEs and serum triglyceride levels in a middle-aged Korean population.

methodsWe analyzed a sample of 2,963 people (aged 30-64 years; 36% men) using baseline data from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort study. The Korean version of the Life Experience Survey questionnaire was used to measure the presence and positive/negative impact of SLEs. Hypertriglyceridemia was defined as a fasting serum triglyceride level of ≥ 150 mg/dL.

resultsOf the 2,963 participants, 33.1% reported at least 1 SLE over the past 6 months and 24.8% had hypertriglyceridemia. Even after adjusting for potential confounders, the serum triglyceride level was significantly associated with the total number of SLEs in men (3.333 mg/dL per event; p= 0.001), but not in women (0.451 mg/dL per event, p= 0.338). Hypertriglyceridemia was also associated with having 4 or more SLEs with positive effects (odds ratio [OR], 2.57; 95% CI, 1.02 to 6.46) and 4 or more SLEs with negative effects (OR, 1.99; 95% CI, 1.16 to 3.41) in men.

conclusionsOur findings suggest that SLEs may increase the risk of hypertriglyceridemia in middle-aged men.

Indexed as

AdultCohort StudiesFemaleHumansHypertriglyceridemiaMaleMiddle AgedRepublic of KoreaRisk FactorsStress, PsychologicalSurveys and QuestionnairesTriglyceridesTriglyceridesHypertriglyceridemiaLipidsPsychological stress

Identifiers

PMID34126706
PMCPMC8289470
OpenAlexW3168422481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.