Evidence map›Paper›PMID 34126554›Full record

SynthesisSchizophrenia research2021

Social functioning and brain imaging in individuals at clinical high-risk for psychosis: A systematic review.

Paul D Metzak, Megan S Farris, Thea Placsko, Amy Braun, Dominique Bonneville, Kali Brummitt, Monica Chu, Jean Addington

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Schizophrenia research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The relationship between substance use and self-reported aspects of social functioning in patients with a psychotic disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul D MetzakHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: paul.metzak@ucalgary.ca.
Megan S FarrisHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: megan.farris@ucalgary.ca.
Thea PlacskoHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: thea.placsko@ucalgary.ca.
Amy BraunHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: amy.braun1@ucalgary.ca.
Dominique BonnevilleHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: dominique.bonneville@ucalgary.ca.
Kali BrummittHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: kali.brummitt@ucalgary.ca.
Monica ChuHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: mochu@ucalgary.ca.
Jean AddingtonHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 3330 Hospital Dr NW, Calgary T2N 4N1, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 3280 Hospital Dr NW, Calgary T2N 4Z6, AB, Canada. Electronic address: jmadding@ucalgary.ca.

Funding

"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2M
3 Cognitive Behavioral Social Skills Training for Youth at Risk of PsychosisR01MH105178 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2014 to 2018
$1.4M
NIMH NIH HHS R01 MH105178NIMH NIH HHS U01 MH081984
6 · The paper itself

Abstract

Impairments in social functioning are a core impairment in psychosis and are associated with poor outcomes. These deficits are found in those at clinical high-risk (CHR) for psychosis, and can persist even in the absence of transition. However, the neurobiological underpinnings of social functioning remain unclear, therefore we conducted a systematic review of brain metrics that have been associated with social functioning in youth at CHR for psychosis. Five databases (MEDLINE, CINAHL, EBM reviews, Embase, and PsycINFO) were searched from inception to May 5, 2020. Studies were selected if they examined brain imaging, and social functioning in youth at CHR for psychosis. Of the 9629 citations found through online database searching, 12 studies with 696 CHR participants met inclusion criteria. Too few studies were focused on the same brain region using the same methodology to perform a meta-analysis, however, loci within the prefrontal cortex were most often associated with social functioning. Few studies have linked social functioning to brain imaging metrics, suggesting that future work should focus on this relationship.

Indexed as

Psychotic DisordersSocial InteractionAdolescentBrainHumansNeuroimagingSocial AdjustmentClinical high riskImagingPsychosisSocial functioningSystematic review

Identifiers

PMID34126554
PMCPMC8380704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.